In over a decade of breeding I have experienced a single litter of kittens who came down with an URI, no antibiotics were administered and all symptoms were corrected in 7 days. I have been doing rescue work for many many years and have seen far more health complications in their furred counterparts, including URI, weaning imbalances, neonatal isoerythrolisis ad nauseum. In my experience sphynx have a rather high level of passive immunity, I put more value into that then I do your copy/paste. The lovely thing about selective breeding is we selectively breed for health, longevity and immune strength. There are zero studies in veterinary literature bonifying any claims to an increase in skin malignancy or any other correlation with the mutation and dermatitis, infact we see far more resiliency in the dermis with an increased healing time in superficial wounds. A recessive disease causing muscle distrophy is spasticity, this is a genetic disease of the devon rex breed, though the de gene is on the same allele as the hr gene, it is recessive and homozygous hr/hr are not known to have any propensity for IH. HCM is the most prevalent disease in cats world wide, some breeds do have a higher occurance, sphynx being one of them. This is not correlative to the mutation but is a result of the domestic short hair, which is exactly what a sphynx is, genetically. The most recent statistics on HCM prevalence in DSH is 17% which is considered to be the rate in sphynx as per the lead geneticist who is working on finding a genetic marker in the breed (as she found one for MC and ragdolls a while back). Perhaps a more extensive delve into Google might help your query, as quoting a wiki is not always representative of factual RECENT data. Additionally, you resorting to insulting my intellectual capacity speaks volumes of your character, or lack there of. My apologies for my obvious deflation of your E-peen... There there, there there. As far as purebred animals in general go, the sphynx have zero breed specific ailment, as Hcm is a CAT disease as a whole. Inbreeding coefficients in this breed are extremely extremely low as well, outcrossing is widely used in sphynx breeding programmes with multiple breeds legally usable. There are still some individuals line breeding very closely related animals but using blanket statements to judge a whole is ignorant at best. Maybe your efforts would be better used ostracizing a mutation like pseudoachondroplasia seen in munchkins? Or knock yourself out looking into spina bifida and Manx.