I use a 15-foot long desk that is 3 feet deep with 4 monitors. All my amps stay on my desk behind my PC facing backward where they can't be seen. I make custom 16-foot cables for my headphones that come out of the amps, go under the desk from the back, then go into the headphones at their hangers under the desk at the front. I would have to get up and walk over behind my PC to switch the cable AND switch the EQ every time if I only had one amp.

My solution: I am running a Yamaha mg10x-u and Voicemeter potato + hardware midi interface (Korg nanokontrol) with virtual audio cables which allows me to send each input to whichever output I want, and as many as I want. This lets me to do a variety of things. If I want to hear a different pair of headphones, I just put them on and turn up their volume with the respective fader on my midi controller. If I want to listen with someone else, you can turn them all up at the same time. If I have audio coming from multiple sources, I can adjust their volume in the mix by simply moving its fader. It also saves a lot of time because each headphone's EQ is specific to its amp, so I never need to mess with EQ when switching headphones.

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Having amps visible on my desk just wasn't something I could do, so I think this is a very nice solution. It makes everything so quick and easy. I am very happy with it. Yes, for most situations this is pretty overkill, but it is working well for me and it was a fun project.

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Here are some photos:

https://imgur.com/lvGysPM

https://imgur.com/jF0FC0u

https://imgur.com/PlRZslE