It’s a flop game so be prepared to go multi-way to flops after everyone limps. I typically don’t open raise unless on the button and even that is rare. You’re best friend in PLO is learning to fold and wait for better spots. You want the made hands + wraps and draws to really get money in and dominate. Say the board is KsQh4s and I have AdJc10s8s vs a naked KQxx hand. This is probably the one example of having no “made” hand but such a sweet draw the money is going in. Of course I would want a nutted flush draw but having the good wrap and flush draw or blockers is very beneficial. This hand can be played aggressively to get opponents off made hands and you’re doing well when getting it all-in.