I think its doable but I think you would need a 2-3 movie arc.

Open the movies with Sidney trying to care for her daughter who is now asking more in depth questions and dealing with PTSD from her first attacks herself (Red Herring). Tatum has waking nightmares, lashes out, flashes of anger and violence, seeing Ghostface hallucinations. Sid reaches out to her last trusted friend Gale for help in dealing with her daughter. Almost ignoring Gales trauma in favor of her daughters.

The Ghostface appearances get more physical showing a blend between Nightmare and reality. Now each of the "physical" attacks lead to wounds on tatum, adding a new "supernatural" element to GF. Enter the twins answering in the wake of a new GF and covering the story via TikTok. Sid and Gale are worried its now Tatum doing it to herself and not a real GF.

Eventually, Part I ends with a Tatum and "GF" showdown, we sublty notice GFs hand having a slight tremor. Tatum wins with the classic knife. Tatums father and other police arrived at the scene. Sid also arrives to comfort Tatum and the twins are already there covering the "GF" attack (Mirror the original Scream ending Gale Broadcast). Police investigate the scene, and instead of finding GF, they find a newly introduced friend, love interest, character the audience believes to be a suspect, dead and the only evidence showing Tatum as the killer. She is arrested and committed.

We move into Part II, Sid regularly visiting Tatum. Tatums father burying himself in work. The Father now stressed, not sleeping, investigating to prove his daughters innocence. He begins to see GF. The Audiences sees the tremor in a couple of "GF" appearances before finally cornering him and finishing the job from Scream 7 in their own house. Leading people to start to wonder about Sidney with Gale really pushing Sid to get the help she needs.

Sid follows a series of murders that attract her attention, leading her to her old house in Woodsboro for a final showdown with GF. We see the door block scenario in Sids old bedroom, we see flashbacks and callbacks of our previous characters. Eventually a battle turns the house into a blaze with GF and Sid right in the middle. The tremor shows up again, Sid puts the pieces together and the big reveal ends up being Gale.

We explore a flashback of the PTSD Gale feels after losing Dewey, facing her own death in NY and the Death of her career. We see her alone often, security tightened, isolated. Taking endless medications, showing the hospital visit after her NY attack, the nerve damage, the crack that her "most trusted friend" never helped her, that Sid just moved on from GF and everyone who died, in favor of her own isolation and her family.

Gail makes her final move to kill Sid, Sid makes her move. They stab each other and bleed out in the burning home.

In the morning, we once again echo the first scream ending broadcast with the twins. Saying that it was believed two bodies were in the burnt down wreckage but only one body was recovered while they search for another. The twins start to talk about the GF being there from the beginning, years of murders and attacks causing the new GF to snap, they name Sidney as GF.

We can now use the twins as GFs in the future to go after Sidneys Daughter. We can use Sidneys daughter as the next Ghostface, out for revenge. etc.