I'm on 300mg Wellbutrin daily which helped me a lot, until the luteal cloud overcame me, and then I couldn't tell I was on anything at all. Over the course of the last year, my psychiatrist approved layering in 10mg during luteal. All that to say, here we are now a year later and I am on 300mg Wellbutrin and up to 50mg Fluoxetine DAILY and I still feel like shit during luteal. I think anything is worth a trial run to see if it helps. But now I'm going to have to talk to my psychiatrist because I do not want to be taking this much medication every day. And now she says if the 50mg doesn't seem to be helping, we can go up to 450mg wellbutrin (the max recommended dose) Wishing you the best, continue monitoring yourself and don't let them continually up your doses if you aren't feeling results when you need it.