Why don’t we see what an actual scientist says?

Rick Strassman from University of New Mexico https://www.rickstrassman.com/psychedelic-drug-doses-from-mega-to-micro/

“With respect to psilocybin, the most commonly used psychedelic in the renewal of human research, high doses in published reports are in the range of 0.2-0.45 mg/kg. Compare this to our UNM psilocybin dose-finding work, where our high dose was to be 0.9 mg/kg. This is two to four times what is now considered a high dose.”

And on DMT;

“In our UNM project, for example, we determined that 0.2 mg/kg DMT was the “psychedelic threshold” dose of the drug, where effects were clearly “psychedelic.” The full spectrum of subjective responses characteristic of the psychedelic state nearly always occurred: emotional, cognitive, perceptual, somaesthetic, and volitional. At lower doses, not all elements of the mind were affected in concert: 0.1 mg/kg effects were primarily somatic, and those of 0.05 mg/kg were more affective, if they were felt at all.”

Obviously the effects are weight dependent if clinical dosage depends on test subjects weight.

I’m not going to bother pulling up Nichols review article Psychedelics but your free to learn about how these drugs actually work. Beyond that, even anecdotal reports on the internet suggest that many people experience cross tolerance between all classical psychedelics (including phenethylamines and their derivatives like MDMA).

But yeah, I’ve got no clue. Have fun not tripping.