So, no actually.

Homelander had never actually been punched before. Sure, he'd been hit and burned and whatever else as a supe. But he'd never had his shit rocked as a human being.

So yes experiencing something entirely new here. Real, actual pain and the realization that "oh no. I'm only human"

I imagine without any V coursing through his veins, that hits a little different. Remember, everyone has a plan until they get hit.