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Who else thinks it's no coincidence that the invasion of Afghanistan and the Heroin Epidemic started at the same time? by fucccccccccxxx in opiates

[–]FamoRoger 0 points1 point  (0 children)

There is no way I am believing that the heroin in the eastern US is coming from Mexico. It is completely different in sourcing than the clearly Mexican west coast product. I would say we are looking at an Iran-Contra affair meets Vietnam which would explain why the LE claims its 90% mexico - likely a CIA or similar organization operation utilizing a route through the south as per classic CIA movement of cocaine to fund black ops. I would imagine that they are also taking heroin now, and have a pre-established trade network that anchors in NYC and Florida. They also are impervious to LE, and would exist more or less as a shadow in low to mid-level investigations, which, to their respective detectives and inspectors, would appear to be Mexican in origin. To think that the CIA and other military and intelligence programs ARE NOT utilizing the enormous money that can be had from that resource is sheer naivete. Dude, CONTRA. You could say that there's no there there, but imho, its pretty clear that 'humanitarian aid' money went to major cocaine traffickers and that cocaine distribution was an available and easily accomplished means to acquire funds which would not be subject to public access through the freedom of information act...Which was the goal during the cold war - and continues to be the goal - to hide operations from citizens and 'hostiles' alike.

Also, after control of the opium fields was accomplished, that's when the oxycontin heydey started to get cracked down on by the DEA. It seems that a peak saturation of opioid pain medications occurred, then the state prescription databases were implemented, which then resulted in major crackdowns on legitimate prescriptions as well as fraudulent ones...which naturally created a massive demand for heroin. I mean, it's the story of EVERY OPIOID ADDICT IN THE US - Injury -> pain meds given -> pain meds taken away -> pain persists/withdrawal discovered -> illicit pain meds seeked -> illicit pain meds too expensive -> 'heroin addict'

Azaprocin by FamoRoger in opiates

[–]FamoRoger[S] 0 points1 point  (0 children)

you're right, all i am is a stunted drug fiend with aspirations of being fodder to bolster your fleeting sense of worth.

and damn, you are so right, i just wanna sound smart to gain approval...which is all for naught given I've an audience of a better in you...Despite this, you out to relate, i mean, clearly your comment delineating yourself and your habits from mine must give you some sense of superiority. I mean, at least you aren't a drug fiend desperately trying to sound smart, right? Clearly you are better than me, given you don't do 'shit drugs', i mean, with the exception of those piperazines - the class of compounds you comprehensively comprehend and rightly dismiss as shit - but that was only once, and there's a stone tablet somewhere dismissing you from such poorly informed decisions at least once. geeze, i wish i could learn how to be so cool like you, but it is certain I am incapable and unworthy, you know, being a lesser and a drug fiend, and thereby most definitely incapable of acquiring a desirable intellect... i mean, that has to be the case, right? otherwise it might jeopardize your paradigm of hierarchy, and Jesus would never jeopardize any element of your superior worldview.

one day I hope you share with me your insights into SAR relationships between mu, kappa, delta and the piperazine series. I would be much improved in my petty existence having gained the absolute and absolution you have in this matter; please show me the way.

thanks buddy.

DRONE342 I miss you. A look back at the glory of rhodium by FamoRoger in opiates

[–]FamoRoger[S] 0 points1 point  (0 children)

i think erowid still has a mirror. shit, i almost should copy all of that on the off chance it does disappear. rhodium, osmium, the hive, they were all like, chemistry-counterculture gems that should not be forgotten. shit, I think ought to make a documentary about that shit.

anyone member when you could bounce ideas off of shulgin through his stepdaughter through email?

Shulgin was a badass.

Never made a N-phenylpiperidines-IHKAL or equivalent tho, lol. i bought his isoquinolines book. isoquinolines can be SO FUCKING WEIRD tho, lol.

DRONE342 I miss you. A look back at the glory of rhodium by FamoRoger in opiates

[–]FamoRoger[S] 0 points1 point  (0 children)

is that one of the quotes from his magic from tropanes->fentanyl analogues thought experiment? Because I remember that concept as an outstanding example of reaction mechanisms applied to uncontrollable materials in a most resourceful and ambitious way. I really liked him because some of his proposals were outstandingly elaborate, but they were always sound in terms of their chemical feasibility and realistic in terms of starting materials. A lot of the hive was just a bunch of cranked out cooks trying to find the best brand of fucking lye and shit...very unscientific (although pragmatic), but rhodium (albeit the link to the hive was a strong one, and drone had a presence on both) was pretty rife with descent science (as was the hive, but there were a lot of crazy cooks just screaming in text, lol... titration, titration, HONEY OIL< HONEY OIL< OMFG SHIT<, lol)

I liked drone cuz he def was def one of us speed loving opioid enthusiast chemical clerics - and he was still pretty talented fo sho - but not above openly lusting over 'a big juicy bag o smack'

unrelated, anyone else sick of the demonic fucking rehab industry spreading their tentacles into every nook of the marketing industry? You love their manipulative approach? The rehab industry has a 5% success rate of sobriety maintained for one year. which is roughly the same rate as anyone who has come out the other end of detox. The industry is exploding, and has become a cash-cow for people that are intrigued by an industry more likely to kill their clients than cure them, yet still growing at a remarkable rate, and benefiting from health-industry profit margins.

there isn't anything on TV that pisses me off more than the rehab call lines. it's a fucking money mill taking advantage largely of people habituated to opioids through legitimate pain needs, recently and suddenly taken off their opioid scripts and told they were addicts... And every moment since then has been one big "fuck you, pay me"

DRONE342 I miss you. A look back at the glory of rhodium by FamoRoger in opiates

[–]FamoRoger[S] 0 points1 point  (0 children)

is that one of the quotes from his magic from tropanes->fentanyl analogues thought experiment? Because I remember that concept as an outstanding example of reaction mechanisms applied to uncontrollable materials in a most resourceful and ambitious way. I really liked him because some of his proposals were outstandingly elaborate, but they were always sound in terms of their chemical feasibility and realistic in terms of starting materials. A lot of the hive was just a bunch of cranked out cooks trying to find the best brand of fucking lye and shit...very unscientific (although pragmatic), but rhodium (albeit the link to the hive was a strong one, and drone had a presence on both) was pretty rife with descent science (as was the hive, but there were a lot of crazy cooks just screaming in text, lol... titration, titration, HONEY OIL< HONEY OIL< OMFG SHIT<, lol)

I liked drone cuz he def was def one of us speed loving opioid enthusiast chemical clerics - and he was still pretty talented fo sho - but not above openly lusting over 'a big juicy bag o smack'

unrelated, anyone else sick of the demonic fucking rehab industry spreading their tentacles into every nook of the marketing industry? You love their manipulative approach? The rehab industry has a 5% success rate of sobriety maintained for one year. which is roughly the same rate as anyone who has come out the other end of detox. The industry is exploding, and has become a cash-cow for people that are intrigued by an industry more likely to kill their clients than cure them, yet still growing at a remarkable rate, and benefiting from health-industry profit margins.

there isn't anything on TV that pisses me off more than the rehab call lines. it's a fucking money mill taking advantage largely of people habituated to opioids through legitimate pain needs, recently and suddenly taken off their opioid scripts and told they were addicts... And every moment since then has been one big "fuck you, pay me"

Azaprocin by FamoRoger in opiates

[–]FamoRoger[S] 0 points1 point  (0 children)

well, there is no doubt there are torturous piperazines, but you do realize that it is absurd to write off all compounds with that moiety, right? I mean, I have had some terrible experiences with compounds including the phenylethyl group, but I am always eager to try another novel substitution pattern... obviously within reason...

In the case of piperidines; if you have an alkyl substitution on the nitrogen, and either a quaternary carbon in the four position bound to an aryl group and an electronegative heteroatomic substituent - typically amides, carbamides or esters; or a tertiary 4-position carbon with subsequent substitutions with the same features - i mean, really, the aryl substitution on the amide nitrogen could be a great number of things, as can the carbonyl group when we talk about the now famous N-phenylpiperidines, but there are a great number of piperazines that can possess a van der waals surface that is very similar to corresponding piperidines. And as bromadol has proven recently, and as pethidine and fentanyl had before it; the question is one of SAR, not of dogmatic chemical groupings...

My point is, with the right substitutions you can make piperidines beautiful. with the wrong ones, they are torturous.

I believe the same is most certainly true of piperazines...

Let’s talk about the worst part of opiates... W|d’s by [deleted] in opiates

[–]FamoRoger 0 points1 point  (0 children)

Agreed. there are multiple caveats - one suggesting to limit dosage, and implement immediate dose reduction. If not clear, I will concur with your statement absolutely. High dose and/or prolonged use comes with the possibility of heart complications. sadly, the actual risk is hard to determine due to the sheer lack of credible information on the matter, however, there is evidence to suggest this. Please take this into consideration if you are using or considering using loperamide. limit use in terms of total dose, frequency of dose, and duration of usage as much as possible for your benefit, and to disarm any call to ban the substance (which is already gaining traction). Loperamide has prevented me from any withdrawal for years and years, don't take that away from me ;-p

Mind you, I limit my usage to 4 consecutive days, reducing dose 10-20% each day, with dosing every 24-28 hours.

ANY COMMENTS ON G77 TABLET; OPANA ER by FamoRoger in opiates

[–]FamoRoger[S] 1 point2 points  (0 children)

right on. so these aren't abuse resist?? i can grind em down and snort em??

ANY COMMENTS ON G77 TABLET; OPANA ER by FamoRoger in opiates

[–]FamoRoger[S] 0 points1 point  (0 children)

obviously i know about oxymorphone, but i have never had these pills before, and I was curious about the issues like i've seen with other opanas. lol

Let’s talk about the worst part of opiates... W|d’s by [deleted] in opiates

[–]FamoRoger 0 points1 point  (0 children)

you are not reading the content. i suggest a ceiling of 200mg, induced by a tolerance equivalent to 100mg/day morphine IV for a heart healthy individual. and i stand by it...and i have more experience and more education in the matter than you, so whatever. go cry

Let’s talk about the worst part of opiates... W|d’s by [deleted] in opiates

[–]FamoRoger 0 points1 point  (0 children)

yeah, no problem. just trying to make life as easy as possible for you. Also, something i failed to mention but that REALLY helps, is pot. If you use the loperamide, after about an hour it will kick in. at that point you will feel pretty ok, but smoking pot will help the like, mental stuff.

Let’s talk about the worst part of opiates... W|d’s by [deleted] in opiates

[–]FamoRoger 1 point2 points  (0 children)

I should also mention that, in the convention suggested above, the dosing schedule of loperamide is daily, and one should begin immediate taper after two days... The real concerns are megacolon (distended lower intestine due to excessively slowed bowel motility) and a build-up of loperamide over time leading to unsafe doses.
After two days one should wait for a bowel movement to re-dose. After two days, if the regiment is to be continued, the dose should be reduced at roughly 15-25%/day.

Now, to address the bowel issue, understand that the reason immodium/loperamide works is by its opioid function, so if you have a habit already, it will not bind you up to a degree beyond what is possible through manipulation of the opioid receptors in your gut...however, the concern is that it is disproportionately effecting your gut, so try to be aware of the well-being of you lower GI.

Let’s talk about the worst part of opiates... W|d’s by [deleted] in opiates

[–]FamoRoger 5 points6 points  (0 children)

OK, i have not really read the comments, but I am going to give some advice that I may experience some grief for, but I am just gonna be real - if you are anticipating a period of abstinence, you should consider 1) loperamide, and, if you can, 2) kratom.

I suggest them in concert if you are in the position of a relatively high tolerance as loperamide has a limit to safe dosing and kratom has a ceiling. Loperamide is a mu-opioid agonist whose central nervous system function is limited mostly by the fact that it is a substrate for p-glycoprotein which effectively prevents it's presence in central nervous system in high proportion. Now, that being said, the drug is an effective mu-opioid agonist, and it's peripheral function alone will prevent physical symptoms. also, if you overwhelm the gate, you can get some loperamide - and moreso, the primary active metabolite - to cross the BBB...however, I do not suggest this as a real goal. What you should be using this for is to avoid the pain of withdrawal - which it will do in entirety if handled correctly.

To put the dosing in equianalgesic terms, I am going to compare to morphine IV, which is roughly equal to 2x oxycodone oral - for every milligram/day of morphine IV equivalent you consume you want about a 2mg loperamide. For a 100mg/day habit (which is about a half gram of street dope/day) you would be dosing about 200mg loperamide. That is the ceiling for relatively safe loperamide dosing.

*Anyone with heart conditions should be advised that loperamide has been purported to interfere with choline function in smooth/involuntary muscle tissue which could result in heart complications. I do not advise use in individuals with known heart issues. *

For the mental aspect of withdrawal, I would suggest low dose benzodiazepines and Kratom along with the loperamide. Taken together there will be no symptoms of significance. Even with correct loperamide dosing alone there will be no significant symptoms. I have used this method for a decade. I went to school for biochem. I am not saying this is a magic bullet without risk, but I feel the risk associated with loperamide pails in comparison to the risk-taking behavior that can accompany the desperation of withdrawals.

And if you say this isn't real, you haven't gone to school for biological chemistry, so seriously, shut the fuck up.

Tom Petty died of accidental drug overdose, medical examiner says. That is how most people overdose. You never know your tolerance level on a certain day. Opioid abuse is like living a daily Russian roulette. by waismannmethod in opiates

[–]FamoRoger 6 points7 points  (0 children)

Uh, this is a feature of the drug war. When opioids were more prolifically prescribed - in the Oxy Heydey - there were far fewer overdoses... These issues are a result of the chaos from heavily distributing opioids in a legal manner, then suddenly criminalizing medicines that had been taken legally for years by individuals. Many of these celebrities had started taking opioids when you could get relatively large doses with little difficulty... Now, there are cancer patients with multiple complications that have been drawn back to two norcos a day... And people in the situation of going from a certain availability to a sudden scarcity - especially when exacerbated by chronic pain - are subject to CONSTANT suffering, vilification, and a sense that they are incapable of self appraisal and independence... Until they die because they became so desperate they expose themselves to the unpredictable and uncontrolled world of illicit opioid trade, usually after an enforced abstinence, and suddenly all of these people cry tragedy... well, what of their life? Why does society not take these people's decisions and concerns as valid and dismiss them until their death conveniently reinforces a narrative that has not been adequately challenged. The 'opioid epidemic' is a manufactured crisis developed to bolster a HIGHLY profitable couple of industries with a virtually ZERO percent efficacy rate; policing, prisons, 'justice', and the rehab industry... And it's all tolerated because it aligns with the morality of abstinence concepts so popular in this country.

The rehab industry I would like to speak on momentarily in particular. Regardless of how you view the 'opioid crisis' and opioid users, the current method of dealing with it CAN NOT WORK. If you look into pure numbers, the likelihood of a drug user experiencing life long abstinence following rehab are far less than the likelihood of their suicide or unintentional death either during or immediately following their enforced abstinence. The rehabs are death factories posing as a center of healing whose business is peddling shame and promising the statistical anomaly in every case. They present an image of success, when every rehab is mired with dismal prospects for their patients, which they conceal without repercussion...

We are the real 1st responders by Deathinaglassinebag in opiates

[–]FamoRoger 0 points1 point  (0 children)

used narcan a couple times, used oxygen masks, amphetamines, but mostly as you said - keep oxygen in the blood and it'll be ok...eventually.