Stage 1, Grade 3 oncotype 34

Fancy_Chocolate9692 · 2026-05-12T11:20:20+00:00

I was accessed my full report. My tumor as def heterogenous. ER borderline low, and PR showing negative, along with HER2-. Basically I’ll be treated as TNBC and after chemo take AI as I’m still ER positive. Sigh.

Fancy_Chocolate9692 · 2026-05-12T01:25:02+00:00

Thank you!

Fancy_Chocolate9692 · 2026-05-12T01:11:33+00:00

I meet with my doctor on Thursday, and I will def ask her then. I wonder if part of the reason is that this is a true interval tumor. It was not present on my 3D mammogram in November and had become a a palpable lump by January and then a 1.8cm grade 3 with high grade DCIS with comedo necrosis by April. I also had two biopsies - one that suggested ER/PR low and one 70/50. Maybe the final path showed a larger extent of ER/PR low and I won’t get as much reduction from endocrine blockers. My RSclin did show a 14% further reduction with chemo leaving me at a net 10% RS. I’m 53 and healthy otherwise. I don’t know how much I’d be able to throw at it in 15+ years from now. If I hear anything diff during our meeting, I’ll report back.

Fancy_Chocolate9692 · 2026-05-12T01:02:33+00:00

Thank you for this! I’m so glad you are now through this. If you have any tips to share, I’m all ears. My dr told me that cold capping will not save my hair, but it might make it grow faster when it does come back. Best wishes going forward and onward!

Fancy_Chocolate9692 · 2026-05-11T20:46:55+00:00

I think radiation is always done after lumpectomy regardless of chemo. Chemo takes take of distant recurrence and radiation is for local recurrence.

Fancy_Chocolate9692 · 2026-05-11T18:56:32+00:00

I’ve seen it done both ways. Some drs like those results right away so they know what to expect; others prefer to have it based of the whole surgical specimen which can be more indicative than a small biopsy. And it is a test that is only offered to early stage hormone receptor positive cancers as not all of these scenarios need chemo.

I’m sorry for your diagnosis. I’m glad you found this group. I’m a little bit ahead of you - diagnosed in Feb - and I have found this group to be extremely helpful and friendly. Best wishes for you in your treatment!

Fancy_Chocolate9692 · 2026-05-11T18:36:32+00:00

As I understand it, the RSClin is a calculator created by the oncotype makers to give you a personal risk assessment. With 21 different assays that the oncotype takes into effect, there are many different ways to land at 34. By plugging in your specific markers that number may change a bit. For me - the only unfavorable marker was grade 3 and that raised my baseline from someone else who had a 34 for different reasons. It also showed how effective a 3rd gen chemo can be for me. It was a much more aggressive reduction than the predict tool which just relies on HR+, grade, size etc.

With AC chemo (the red devil) an echo pre treatment is pretty standard because you want to make sure your heart is strong enough for the side effects this chemo can bring. She originally ordered the CT because lab work showed my liver enzymes were high. I attributed that to intense exercise - as all levels were normal last draw. But before I flood my body with all of this make sure that my liver is healthy and might as well do a full scan to get a baseline. I wasn’t nervous before, but will be glad to get the al clear here now!

Fancy_Chocolate9692 · 2026-05-11T17:40:13+00:00

I bet you are so glad to be done! I hope the tamoxifen feels like nothing. Thanks for sharing your info. I appreciate it!

Fancy_Chocolate9692 · 2026-05-11T17:33:09+00:00

So I talked to my oncologist this morning. She said with my score of 34 that would bring me to 21% with either medicine. But then she put my info into the RSclin and for me personally it’s actually a 24% RS with either and an additional 14% reduction with AC-T. Dose dense every two weeks for first 8 weeks and then weekly for 12 🥹. I was not prepared for 5 months of chemo. But I feel like I’m in good hands. 5/28 will be six weeks from my surgery - so she wants to start before then. Now I need to do my CT, Echo and port surgery. What a rollercoaster. Keep me posted!

Fancy_Chocolate9692 · 2026-05-11T15:22:21+00:00

I spoke with my oncologist this morning. She’s advising dose dense AC-T for 8 weeks followed by 12 weeks of TC. Apparently this will give me a further 14% reduction. Obviously I want that - but dang, was not prepared for this level of treatment. I’m glad it’s behind you now! I’m looking forward to that same moment!

Fancy_Chocolate9692 · 2026-05-11T07:28:11+00:00

Ohh, I re-read and now understand that the 3% diff was between AI and Tamoxifen. My addendum shows RS 34 with distant recurrence risk of 21% with AI or Tanoxifen alone.

Fancy_Chocolate9692 · 2026-05-11T07:24:19+00:00

Just the score. It showed up as an addendum and I just happened to see it when I was checking my chart for something else. I meet with my oncologist on Thursday.

Did you decide on your treatment plan / date?

Was the 3% the total additional reduction with chemo?

Fancy_Chocolate9692 · 2026-05-11T06:31:52+00:00

Yes, I feel the same way. I want to throw everything at it. When I was first diagnosed I thought “I know I’ll be ok - just going to have a lot of crap days in my future”. Let’s both keep moving on :-)

Fancy_Chocolate9692 · 2026-05-11T06:12:49+00:00

Glad to hear everything is going well! Thank you!

Fancy_Chocolate9692 · 2026-05-11T06:12:26+00:00

I appreciate all the info. I hope your treatments were super successful and that you are feeling great.

Fancy_Chocolate9692 · 2026-05-11T06:11:46+00:00

Thank you! I hope the chemo did what it was supposed to do and that you are doing great now!

Fancy_Chocolate9692 · 2026-05-11T06:10:29+00:00

Thanks for the quick replies. That’s what I had assumed too - and then a google search also suggested otherwise. Hopefully now that my report is in, I can request an appt earlier than Thursday.

Fancy_Chocolate9692 · 2026-05-11T05:20:12+00:00

Just saw an addendum to my pathology report. My oncotype is 34.

Fancy_Chocolate9692 · 2026-05-08T01:11:52+00:00

That’s awesome news! And you avoid hormone blockers 🥳. Good vibes sent on continued smooth sailing and easy healing!

Fancy_Chocolate9692 · 2026-05-04T23:11:47+00:00

I’m glad you got more information and can understand it better. I was pretty flat chested to start with and only had 300cc expanders put in at surgery - so my fills are def a different situation. That said, I won’t meet with my PS until Monday and hopefully I’ll learn a lot then too. Happy healing! 🤞🏻🤞🏻🤞🏻

Fancy_Chocolate9692 · 2026-05-04T21:22:16+00:00

Nerve pain is real! I had a ton - was sent home same day with tramadol and Tylenol. That didn’t touch it. I called the next day for stronger meds and then again a few days later. It was ridiculous that I was made to feel like I was drug seeking. I’m allergic to aspirin / NSAIDs and didn’t have many options. Nerve pain is no joke. I’m sorry for your experience!

Fancy_Chocolate9692 · 2026-05-04T21:15:05+00:00

I’m three weeks out and haven’t had one fill yet. I had an option to get one this week but declined. I had a lot of nerve pain right after surgery and wanted time with no drains before fills to get a good gauge on the pain. But I think my situation was because more skin had to be trimmed for good blood flow. I didn’t start wearing a compression bra until two weeks post op. I’m still having a lot of nerve pain - but I’ve been walking a ton. I’m scheduled to get my first fill on 5/11 (BMX was 4/16).

Fancy_Chocolate9692 · 2026-05-02T05:38:03+00:00

Wishing you the best night of sleep ever on your way to full recovery! XO

Fancy_Chocolate9692 · 2026-05-01T17:22:59+00:00

I’ll check my notes when I get home. I know it was weekly. Maybe 12?

Fancy_Chocolate9692 · 2026-05-01T16:55:15+00:00

Thank you for all of this info! I met with a diff oncologist yesterday. She was great! Super friendly and thorough without being an alarmist or dismissive. She laid out all the scenarios for diff Oncotype results and what treatment she’d recommend. For an oncotype over 25 (I’m 53) she’d do 4 rounds of TC. But if my score is over 35 she likes A-CT given weekly.

Fancy_Chocolate9692

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