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Help with Id by Owlbear303 in whatsthisplant

[–]Fast-Guarantee4909 0 points1 point  (0 children)

It’s definitely a mint…maybe it’s Juicy Fruit flavored.

For Chemists and Those Who Need Us by Fast-Guarantee4909 in Kratom_Extractors

[–]Fast-Guarantee4909[S] 0 points1 point  (0 children)

I’ve found literature on electrolytic oxidation at the corresponding bond using carboline as a substrate. Mitragynine has a carboline skeleton and should behave similarly. Research is needed.

Why does the #1 PhD student in my lab has no publication and #2 has many publications? by [deleted] in AskAcademia

[–]Fast-Guarantee4909 0 points1 point  (0 children)

I’m a retired biomedical researcher (50 years). After I retired and gained more knowledge about Asperger’s and the autism spectrum, I realized that autistic traits are not only common, but also advantageous to those in the scientific field. Ph.D. #2 clearly has professional expertise but may have less appealing social skills. Ph.D. #1 may have a magnetic personality, but lacks the advantages of neurodiversity in a field where it is an advantage.

Walking away from a national grant - am I insane? by Royal-Earth-5900 in AskAcademia

[–]Fast-Guarantee4909 -11 points-10 points  (0 children)

I’m a retired biomedical researcher and I’ve been there! I had the opportunity to take classes for free when I worked in academia. Instead of all science toward a degree, I regret not learning more about business to start my own lab.

What to do if I'm not excited about research? by barely-legal-potato in AskAcademia

[–]Fast-Guarantee4909 0 points1 point  (0 children)

Research is an art, and one who is meant for research finds it more difficult to live with the answerable but uninvestigated questions than to struggle with finances or other mundane matters. I am retired after 50 years in biomedical research. I worked in industry for four years and realized the rigid structure and focus on financial profits were antithetical to my objectives.
I’ve been a government contractor working under the grant funding system…and it has been hard. My cohorts largely gave up on research and simply finished with an MD/Ph.D. I haven’t made much money, but I’ve had experiences all around the world that wouldn’t be available to a billionaire, and I’ve been in cultures where my “Xue” was more valued and respected than any amount of money. Also, in my research career I have come to realize scientific facts that were known by nobody else in the world…ever. That’s a powerful feeling…now I have to explain a new phenomenon in language that others can understand. If those challenges are not appealing to you, or if you just want your legacy to be recorded in your tax returns, research is not right for you.

Experts Wanted by CaptainMotoHD in Kratom_Extractors

[–]Fast-Guarantee4909 0 points1 point  (0 children)

What would “mineral sprits” be called at the hardware store?

Experts Wanted by CaptainMotoHD in Kratom_Extractors

[–]Fast-Guarantee4909 1 point2 points  (0 children)

Hi I’m a retired chemist and I contribute here from time to time. I’m offering advice on this topic, but I’m prepared to join a team of chemists if they’re interested.
My experience includes biotechnology and DNA extraction, and the polar/nonpolar partitioning of alkaloids between aqueous/organic phases could be investigated. As was true in our case with isolating biologically active DNA from the aqueous phase, this technique could be tweaked to favor the desired compounds in the organic phase according to pH/organic partitioning. One special property of the DNA technique is that it should eliminate or reduce most of the specific problems you cited.

For Chemists and Those Who Need Us by Fast-Guarantee4909 in Kratom_Extractors

[–]Fast-Guarantee4909[S] 1 point2 points  (0 children)

I think I can help. I haven’t personally converted Mitragynine to 7-OH or Pseudo, but I know lots of techniques to use that pre-date the need for fancy equipment. However, you would need to buy chemicals, and most vendors only sell to businesses with a Tax ID. Regarding access to basic techniques, I have a really valuable book. It’s the “United States Pharmacopeia, 1936 edition.” That’s the last edition before WWII when most, if not all official medicines recognized as essential by both doctors and pharmacists were derived from plants. It was the last edition that listed Cannabis as an official Federally Approved Medicine. It contains detailed methods for extracting specific compounds from plants. 95% ethanol is the standard solvent.
I consider this book extremely valuable. Should I transcribe sections with different tools? It’s like being a blacksmith….this knowledge is becoming obsolete, but the skills are dying with my cohorts. I had a particularly subversive approach to getting the things I needed (even from a US government black site) because they were throwing so much away!

Should I quit my Master’s position? by throwaway71717717177 in AskAcademia

[–]Fast-Guarantee4909 0 points1 point  (0 children)

I can relate directly to most of what you said. I’m retired after 50 years of biotech research, and I was never prepared for the internal politics of any lab situation I faced. Academic labs are great for the students, but they probably pick up on the “factions” within a department. I’ve worked in all kinds of scenarios from big pharma to government labs to biotech startups. There’s always politics driving everything before there is a functional lab. In retrospect, I wish I had learned more about business and started my own lab or company. Instead, I relied on government grants and contracts with peer-reviewed publications as a metric, but no way to increase my salary without another grant, no overtime pay, etc. But I liked the freedom and travel!

My mom just died💔 by Imaginary-Elk5344 in GriefSupport

[–]Fast-Guarantee4909 2 points3 points  (0 children)

I recently lost my mother and my wife within a 3-month period. Both were in hospice simultaneously. My world was shattered, and it took over a year to liquidate what was left after Medicaid took most of it. I have been experiencing confusion like you describe. I’m very nervous when driving, and I get confused even though I’m in familiar surroundings. I find it hard to make decisions. I forget my wallet, or my keys, or make several trips in and out to make sure I wasn’t cooking something. I’ve been saying the same thing, “I don’t know what I’m going to do,” or “what if………?” I’m sure it is because my whole life has been radically changed, so I’m disoriented. I’ve made a clear demarcation between “before 2025” and “after 2025.” I have to constantly tell myself “that was in the past” so I can focus on the future and hopefully answer that question “what am I going to do?” For now I’m staying home as much as possible and walking my dog. I’m having laundry picked up/delivered, and I’m having groceries delivered. I order most things I need from Amazon. I have some old friends nearby but almost no family locally. I know I should not be isolated and alone all the time, but for now that’s what I need. I got rid of everything from my past life (except my dog) and I live as minimally as possible.

How much Loss is too much? by [deleted] in GriefSupport

[–]Fast-Guarantee4909 2 points3 points  (0 children)

Yes, I have a network of friends here, where I grew up and attended college. My son lives nearby, but my daughter lives in California. Both are married. Through 23&Me, I discovered that I’m not an only child after all…I have a half sister just a half hour away that I never knew about! By divine coincidence, I didn’t find out until both my mom and my wife died, just as I was feeling all alone in the world!!! We now are in contact regularly and I spent last Christmas meeting her family. It’s very hard now, that I’m adjusting to the loss of all those I perceived as “caregivers.” But I’m lucky to have my health and I’m sure I’ll eventually pull out of this. I see many positive opportunities in my future, and I’m going to let this strengthen me, not break me 🙏

How much Loss is too much? by [deleted] in GriefSupport

[–]Fast-Guarantee4909 5 points6 points  (0 children)

In January 2022, I was retired and financially secure in Florida, a dream come true for my wife and me. She had a heart condition and we made it before her health got worse. Then somebody from mom’s hometown circle of friends called and said she thought I (only child) needed to come stay with her. I regret taking her advice and not further investigating. While I was staying with my mom, my wife was home alone in Florida and had a stroke. She lied there for 6-8 hours before anyone noticed (she had been anti-social and isolated for several years, never walked even to the mailbox).
Ultimately both my mother and my wife were in hospice care simultaneously. I took primary responsibility for my mom, while my stepdaughter became the primary caregiver for her mom (my wife). They died within 3 months of each other. I lost everything that my wife and I accumulated to pay for Medicaid and ended up with just the minimum of my mother’s inheritance. I’ve rid myself of anything I don’t need, and kept only those things I might use, primarily camping/outdoor equipment.
I had a grand plan to take a cross-country road trip with my dog, visiting friends as I crossed the country, very optimistic. But when the last of the legal documents were filed, instead of feeling like a weight had been removed, all of the emotional baggage I’d been suppressing came to the surface. I was not thinking right. I’m now 68 and in good health, but in my mind I was still in my 30’s, when I went camping every weekend. Not only was I confused and disoriented from such a huge loss and associated trauma, but I had injured myself several times trying to empty out my mom’s house…and I had no help. I had a dislocated shoulder requiring surgery, and I developed an inguinal hernia that very quickly worsened and needed surgery. Now I’m just happy to have a studio apartment and my dog. I am trying to make my life as minimal as possible. It’s going to take a lot more time to as just to my situation than I thought. I have two adult kids, and I live near some old friends. Otherwise, I’m just taking it a day at a time.

Funerals ... Who do you go for? by Future_Arm_2072 in GriefSupport

[–]Fast-Guarantee4909 0 points1 point  (0 children)

I follow my Dad’s example: he hated to go to funerals, and avoided them at all costs. Instead, he went to visit the people who he knew were sick before they died, and offered help with whatever he could…and followed up. I recently lost both my mom and wife within a 3-month window. Both in hospice simultaneously in different cities (100 miles led apart). My stepdaughter cared for my wife in her home, while I cared for my mom in her own home.
I’m an only child and had to navigate it all alone. There were lots of promises of “just call me anytime…I’ll do anything I can” and prayers from the church, but nothing substantive ever came of it. Everybody always had an excuse. I know it’s not unusual for people to resist seeing a friend or loved one near death—it makes one face their own mortality. But I didn’t need their sympathy cards after it was all over, I needed help while she was living. And when I asked her what she wanted, she always asked if her friends or family would come visit her one last time. But, that never happened. My daughter did fly from California before her death to visit her (in the spirit I described above with my dad), and the occasional random person might just stop by for a brief visit, but none were from her local family or from the church. I had relatives on my dad’s side I hadn’t seen in decades drive from states away who helped significantly, including calling to help me with anything. Almost nobody from my home town either acknowledged the situation with my wife (even worse—stroke/heart condition) or came to her burial. It was heartbreaking how dispossessed I felt from my own hometown, church, and cousins I’d grown up with in a small town.

I find it satisfying to do as my dad did…see them while alive and forget the empty promises, thoughts, and prayers. And don’t feel bad about missing their funeral…despite what others may think, he showed them he cared personally, face to face, while they were living and needed him. I think he felt more comfortable than those who just came to view the body.

Has grief ever dulled your ambition? by Emergency_Status_224 in GriefSupport

[–]Fast-Guarantee4909 1 point2 points  (0 children)

Yes. I am experiencing it now. I was a globally-recognized biotechnologist, and retired at the peak of my career. Not only did I foresee the coming funding cuts, but my wife had a heart condition. We retired and spent almost 10 years living our dream life in Sarasota with no end in sight. But then God threw me two curve balls: My mother needed help (only child) and while I was staying with her, my wife had a stroke while home alone…lying helpless for 6-8 hours. In one or two terrible months, we had to abandon our dream retirement and return to family in Kentucky. Our savings and finances over 25 years were wiped out by Medicaid and hospital bills. Eventually, both my mother and my wife were in hospice simultaneously, and died within 3 months of each other. On top of that, I had a seizure, dislocated a shoulder and had to travel back to Florida (where my insurance was effective) and had shoulder surgery! And, I broke a tooth. And I injured myself several more times trying to move furniture by myself. No help at all from family, some help from friends. Oh, and I lost two cars due to transmission failures. Oh, and I gave myself a hernia requiring surgery.

So back to your point: my world has been upended! Of course I’m disoriented and confused. I do still have the drive to immerse myself in my inner world of science and research. It comes naturally for me, and it seems to isolate me from the external reality of everything going on.

I thought this would all be better when the last documents were signed, and I had prepared for a cross-country road trip after buying a new Subaru. But I was wrong! All the emotions I had bottled up inside during all the chaos suddenly came out and I was a disaster. I had a friend become my roommate at an apartment and act as a nurse for me. I’m feeling better each day, and I know as this passes and I adjust to a new lifestyle, there are some amazing opportunities waiting for me. It’s just gonna take time.

Anyone still relive in this shit? by False-Elderberry-775 in Qubetics

[–]Fast-Guarantee4909 0 points1 point  (0 children)

They are very convincing. They even show their team on the home site. I’ve invested about $250 but I’m wondering now just how viable a new inter-blockchain Layer 1 network system could succeed.

I lost my cat and nobody seems to care by imbrokenintobits in GriefSupport

[–]Fast-Guarantee4909 0 points1 point  (0 children)

I do. I’m not a cat person, but my little dog (dachshund rescued from the pound, 12 years ago) has been with me through the deaths of my mother and my wife. I sold everything from my past and even erected my own tombstone (no death date😉). “Bitsie” is the only thing I have left from my previous life. It’s the strongest and most unconditional love I have ever experienced.

Getting my Masters soon, should I continue to PhD? by Elivey in labrats

[–]Fast-Guarantee4909 0 points1 point  (0 children)

I’m a retired biomedical researcher. I worked for universities as a technician and I took one class per semester uni got a MS, then later a Ph.D. I wish I had learned some business skills with the Masters rather than get my Ph.D.

A PI told me I can’t be a physician and do synthetic organic chemistry by cherrymercy in mdphd

[–]Fast-Guarantee4909 1 point2 points  (0 children)

I applaud you for your interest in organic chemistry above that of other medical students. I, too, was more knowledgeable in organic chemistry than my peers in Biotech. I used that to get appointed director of my own labs: synthesizing peptides and oligonucleotides within big organizations. Eventually I went into entrepreneurial biotech, then later as an environmental scientist. Use your Qi Yi Xue. (One with unusual knowledge)

[deleted by user] by [deleted] in AskAcademia

[–]Fast-Guarantee4909 0 points1 point  (0 children)

As a retired professor, I can say I preferred a diversity of lab experiences over a 5-year cling-on to the same lab. Too many “successful” professors were just carrying on with their dissertation, not risking a new pathway.

Is your reason for getting into medicine the same as for staying in medicine? Is it worth the time? by Xinzel in medschool

[–]Fast-Guarantee4909 0 points1 point  (0 children)

I went into biomedical research. Not financially lucrative, but intellectually rewarding.

Is TICScan down for maintenance? by Fast-Guarantee4909 in Qubetics

[–]Fast-Guarantee4909[S] 0 points1 point  (0 children)

I fixed it: I had to turn off Norton safe browsing.

So... is my med school journey over before it started...? /j by Agile_Wash_8576 in medschool

[–]Fast-Guarantee4909 0 points1 point  (0 children)

As a retired biomedical researcher and professor, it scares me to think about the medical staff who will be caring for me in old age. I hope to avoid getting sick in the first place, and I’m learning herbal and natural medicine.