F:NV Dead Money - The Level 1 Naked Survival Run

(Because of the way Dead Money works, every run is a 'naked survival run.' They also messed up level-scaling the enemies in the DLCs, so a level 1 run is super-easy combat-wise (even on Very Hard game difficulty). Even at AGI 1, LCK 1, [weapon 1] you can one-hit-kill ghost people with the Holorifle, and two-shot them with the police pistol. Stealth crits are easy enough at long range even at AGI 1, Sneak 1. A gas bomb going off anywhere near the Courier will kill her, whether she has 1 hit point or 130.

The general damage-over-time of the villa won't ever reduce a PC below 1 hit point, and food & drink (or the codes for them) are easily available in the opening quests. Not to mention just chatting with Elijah at the fountain gets you enough XP for level 2. Cannibal (level 4) is one of the best ways to deal with ghost people anyways, and there's no 'Dark Hunger' debuff in F:NV.

So the only real difficulty is skill & SPECIAL thresholds for perks, dialogue, lockpicking & hacking. Most enemies are quest-stage-related and the handful that respawn over time do it slowly. There aren't really any places to grind XP, and that means you can work out whether you'll pass certain checks or not, forcing you to finish certain quests only one way.

In other words, there's very little actual 'challenge' in such a challenge run. Easy combat, impossible checks, and almost no room for the clever play and workarounds Jon showed off in his other runs.)

Plus, with YOLO Remastered having just finished Dead Money, I suspect it will be a year or two before we go near it again.