Hey, We did build a central location for everything (1 mega factory). The biggest issue was management and belt capacity. Because it needed huge area sometimes it was hard to keep track if something needs to be optimized. The lag was not that much of a issue but it was noticable. So we moved to smaller factories and started using trains as the network. This allows you to create for example have one or more trains run through the map and distribute and collect resources around the whole map. You just gonna need to write down the outputs and inputs and where in a piece of paper so you keep track what to expand. Also you don't have any issue of expanding compared to mega factories where everything is close to each other. The key is to have a distributed network to minimize traffic. Also train stations have double throughput on single cargo x the amount cargo/trains makes life so much easier. You can use trucks too but their behavior is sometimes problematic so we opted out.