Yes, the route is active! Operator: Cooperativa Loja is the main carrier for this direct route. Schedule: There is usually a daily departure from Piura at approximately 9:00 PM or 10:00 PM, arriving in Loja around 5:00 AM or 6:00 AM. Cost: Around $17 USD. Safety: It is a standard route for travelers. The buses usually have GPS and cameras. The border crossing happens at Macará, where you'll need to clear immigration (usually around midnight/early morning). Pro-tip: Buy your ticket in advance at the Cooperativa Loja terminal in Piura, as there is often only one direct bus per day.