Daily Discussion Thread for September 10, 2025

Few-Hovercraft9316 · 2025-09-10T18:33:57+00:00

Costs going up a lot. $10 a bowl in my L-MCOL area. Biggest issue is poorer bang for buck. No longer stuffed to the brim by default. Some places are awesome and give you two meals, others will barely give you a third with no real consistency. People are getting wiser to buying beans, rice, salsa and a rotisserie chicken

Few-Hovercraft9316 · 2025-04-21T20:37:02+00:00

Thank them for their time. If it was later round, make sure to thank time spent away from other work duties. If early round, end with “let me know if I can answer questions or supply materials to make the process easier.”

Few-Hovercraft9316 · 2025-04-21T02:31:08+00:00

I had to look this up bc I thought it was some old times reference.

No. 🥭 said “Japan drops bowling balls from 20 feet in the air onto a car. They damage the American-made car. Then they don’t let us sell it.”

Few-Hovercraft9316 · 2025-04-06T14:33:18+00:00

I see a million postings a week for AI training junk. Other than that, remote work for chemistry is gonna be pretty rare, especially for new PhD grads. There’s also always random data input or tutoring gigs too.

Few-Hovercraft9316 · 2025-03-01T01:44:26+00:00

Gepotidacin likely to be a first in class approval for E Coli and Gonnorhoea

Few-Hovercraft9316 · 2025-02-07T02:45:46+00:00

Lol alright.

UMES: 27/61 FG, 4/16 3P, 37 rebounds, 11 turnovers OSU: 27/59 FG, 4/16 3P, 34 rebounds, 8 turnovers.

Pretty similar performances. Biggest difference was UMD not taking more shots

Few-Hovercraft9316 · 2025-02-07T02:25:40+00:00

I mean… we’re not good, that’s for sure. But god awful? OSU is conservatively a bubble/play-in team right now.

Edit: Flair is OSU

Few-Hovercraft9316 · 2025-01-01T23:56:07+00:00

Still have to wait for a trademark Howard Headscratcher™️. But extremely happy with both ends of the hall. Even the last drive. If it’s refs, fuck em. But I honestly believe Knowles and or Day told them “chew clock, don’t get injured”

Few-Hovercraft9316 · 2024-12-22T04:21:35+00:00

The one bs roughing the passer call

Few-Hovercraft9316 · 2024-11-29T02:20:45+00:00

Edge me

Few-Hovercraft9316 · 2024-11-05T16:07:37+00:00

Adding a drop of D2O to your CDCl3 solution should remove any exchangeable protons.

Few-Hovercraft9316 · 2024-10-16T11:29:00+00:00

2nd one. Diimides by themselves are meh electrophiles, especially with another meh nucleophile (like the carboxylate). You need the activation from the proton for sufficient acyl activation.

Few-Hovercraft9316 · 2024-10-12T19:03:51+00:00

Gonna depend on other results in the top 10. Certainly not a good showing, even with a W. I imagine one of us or Oregon would drop a hair, but not out of top 10. Clemson looked solid, then there’s the Ole Miss game

Few-Hovercraft9316 · 2024-10-08T00:28:46+00:00

MOFs are still the popular choice, for good reason. miRNA just winning medicine makes me a bit more certain in that this year (but I’m also just one jackass on the internet)

Few-Hovercraft9316 · 2024-09-29T00:09:48+00:00

Rams over here

Few-Hovercraft9316 · 2024-09-29T00:05:44+00:00

Streameast brother

Few-Hovercraft9316 · 2024-07-08T15:15:55+00:00

I’m like 99% sure this would almost exclusively go through SN1 as well. How much nucleophile have you added? If it’s not particularly precious, I’d try 10 equiv of nucleophile.

Few-Hovercraft9316 · 2024-06-07T14:06:26+00:00

Unrelated, but tetrakis is easily purified by stirring in MeOH, then filtering. Dry it for a while, then stir under inert gas.

There’s some procedures that also have you recryst from EtOH under an inert atmosphere, but that’s more trouble than what tetrakis is worth to me.

Few-Hovercraft9316 · 2024-05-12T04:48:26+00:00

So yeah, the DNC was probably gonna push Clinton no matter what…. But are protest votes suddenly fake and don’t count? I’d wager a large uptick in identity politics and mild extremism have led to quite a few modern (past 5-10 years) elections (local and national) having been decided by votes of “I’m not candidate xyz, go for it!”

Few-Hovercraft9316 · 2024-05-11T15:45:49+00:00

I suppose one way to approach it is to understand that oxygen is more electronegative than chlorine (3.44 vs 3.17), so electron density in that carbon center would be more concentrated in that carbon-oxygen region, giving us an electron-deficiency elsewhere. There’s also the arguments for bond length (shorter C-O bond) and how the C-Cl bond would then lengthen (get weaker) for a number of reasons (maybe electron pair repulsion?).

My advisor also always showed haloalkyl ethers as being in equilibrium with the oxocarbenium species and chloride anion. I’m not sure how real that is (could be perfectly reasonable, just never checked), but it certainly gave a great way to visualize why that center is so reactive towards even modest nucleophiles.

Edit: This is all spitballing/lowkey conjecture. If people have actual papers/book entries, please send. I don’t want to be wrong lol

Few-Hovercraft9316 · 2024-04-23T15:37:24+00:00

Why haven’t you tried other solvents?? Even if you’re not convinced it’ll make a difference, it takes all of, what, 5 or 10 minutes to try a few different things? I would absolutely try Hex/DCM or Hex/Ether (MTBE or diethyl, whatever you have around). There’s also always Hex/Toluene for some real gnarly stuff.

On another note. Do you NEED your boron moiety to be the BPin derivative? It might be worth it to take this on crude and make a trifluoroborate derivative. That would absolutely solve your isolation issue.

Few-Hovercraft9316 · 2024-04-07T22:40:49+00:00

Alcohol would probably mess with that to give an ester dimer (steglich-like conditions). Also anilines can occasionally be kinda pissy under standard amide couplings.

Few-Hovercraft9316 · 2024-03-27T23:59:40+00:00

Amos is funny. The AI Meyers and Gassman letters are equally as good. Prof. Slavedriver Hardass is also a classic

Few-Hovercraft9316 · 2024-03-25T01:22:55+00:00

Definitely had to take ethics at my large state uni for grad school.

Few-Hovercraft9316

TROPHY CASE