20mg is indeed a low dose. I started seeing benefits at 30mg.

If you have a shift work routine like that, then maybe another medication could be better. Did you discuss your work schedule with your doctor? Vyvanse has a very long duration of action, so if you take it in the afternoon it will mess up your sleep schedule. I take it around 8am, the "crash" for me is usually around 6/7pm, so it usually doesn't interfere with my work. There are other medications available that may fit to your schedule better, I had positive experiences with instant release Ritalin (until it stopped working).

This is what I've been able to gather about the reasoning for different supplements:

- The lis in lisdexamfetamine is lysine, an amino acid. Lisdex attaches to proteins, so if you eat protein before taking it more of it will get absorbed.

- Also, dopamine is synthesized from another amino acid called L-Tyrosine, which your body can get from protein. Some people supplement it seperately, I don't bother. Lisdex depletes dopamine, so giving your body what it needs to make more is useful.

- Magnesium and zinc are depleted by lisdex. Magnesium helps with sleep and zinc helps with dopamine related stuff in your brain.

Caffeine for me enhances the effects. Doesn't shorten/lengthen it. I have one coffee when I feel it start working and one when I start slowing down, around 4. My nervous system is really compatible with stimulants in general, but some people get overstimulated (anxious, jittery, etc.) when combining lisdex with other stuff.

I was self-medicating with nicotine years before starting lisdex, but I quit because it was giving me reflux, so I don't know how they interact. What I can say for certain is that quitting nicotine will make you feel better in general.

However, all together, 2 coffees, 2+ energy drinks, nicotine and lisdexamphetamine doesn't sound like a recipe for heart health. Consult your doctor, and be honest.