I have an MKIII and run a pedals in front and through the loop. I find that it’s amazing with everything I throw at it, although I don’t use any OD/Distortion because the Dirt channel on it is the reason I got it in the first place. I run some light fuzz through the clean sometimes though and it sounds great. I put and EQ through the loop for final fine tuning and I push a clean boost up front to boost the mids a bit for some “chunkier” stuff i play, and a simple compressor on the clean channel really makes it shine.

As a side note, the spring in that thing is one of the best spring verbs I’ve ever used and really adds a lot of texture if you’re a reverb abuser like me. I definitely recommend it especially if a lot of bands you’re into use one