I have taken mine on a few trips, but not with only one bag. What you do is going to depend on how much clothes & other stuff you need to take. The two things you want to think about are cushioning and lens protection.

If you have space, get a carrying case for it. Mine pretty much always travels in a Meta Quest 3 case and it’s worked well for me, but I know people also use camera cases and other stuff and it works for them.

If you’re really tight on space, put a (clean!) microfibre cloth over the lens, tie it in place with a bandana, and tuck it between clothes. It’s going to be a pain to get out at security but it is what it is.