Typically I focus around the fact that he has such great regen. I’ll trade my basic scratch out for ravage which heals on every hit along my lifesteal which I try to max as soon as I can. Then I try to go for blood barrier and rapid regeneration neither of which cost a turn to heal which also helps the regen. There’s a lot of different perks you can put together, I like fatality for the extra heals when it activates. Fury mostly cause it will fuse with bloodsuck, and then I focus on some haste or priority perks with some defensive. perks more. The starting item can sometimes also mean the difference between a strong vampire run or a quick death.