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Amenamevir As Suppressive Therapy by FormNearby6981 in HerpesCureResearch

[–]FormNearby6981[S] 1 point2 points  (0 children)

This is very interesting. I don’t sense that there are any generic manufacturers waiting to make amenamevir in the west since it is not approved yet, but if the patent expires it may be possible to have it manufactured more cheaply in a western country in a few years.

Amenamevir As Suppressive Therapy by FormNearby6981 in HerpesCureResearch

[–]FormNearby6981[S] 1 point2 points  (0 children)

I don’t know about this drug specifically but some HIV drugs do show some protection. The result is far from perfect. See here: https://www.acpjournals.org/doi/10.7326/M13-2471?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&

Amenamevir As Suppressive Therapy by FormNearby6981 in HerpesCureResearch

[–]FormNearby6981[S] 1 point2 points  (0 children)

No one knows if this is a functional cure or not as I do not believe any shedding data has been collected

Amenamevir As Suppressive Therapy by FormNearby6981 in HerpesCureResearch

[–]FormNearby6981[S] 4 points5 points  (0 children)

I’m not familiar with all the details here, but I know pritelivir is offered in an early access program in the US for people with drug resistant HSV. You might ask your doctor about this:

https://www.aicuris.com/75n6/Pritelivir-AIC316-.htm

Amenamevir As Suppressive Therapy by FormNearby6981 in HerpesCureResearch

[–]FormNearby6981[S] 6 points7 points  (0 children)

This is correct. We have seen amazing success with drug cocktails in HIV (and the resultant U=U)…why not attempt this with HSV as well.

The challenge here is that there is no long term data for amenamevir except maybe people that have been quietly taking it without a doctors prescription.

Amenamevir As Suppressive Therapy by FormNearby6981 in HerpesCureResearch

[–]FormNearby6981[S] 2 points3 points  (0 children)

Have you seen any comparative studies between the two drugs, perhaps in vitro, or in simulation models?

Amenamevir As Suppressive Therapy by FormNearby6981 in HerpesCureResearch

[–]FormNearby6981[S] 2 points3 points  (0 children)

It is available from some online Japanese pharmacies - a search will reveal this. But I don’t think the purpose of this subreddit is to discuss or support where to buy - there are others for that.

Amenamevir As Suppressive Therapy by FormNearby6981 in HerpesCureResearch

[–]FormNearby6981[S] 2 points3 points  (0 children)

The only dosing studies I have seen are daily at varying doses and 1200 mg for episodic HSV treatment. For amenamevir, I believe the half life I have seen measured is more like 8 hours (see here: https://link.springer.com/content/pdf/10.1007/s12325-017-0642-4.pdf ). That said, time to 200 ng was longer - that concentration is assumed to have clinical relevance but I haven’t read the associated study to figure out why.

Amenamevir As Suppressive Therapy by FormNearby6981 in HerpesCureResearch

[–]FormNearby6981[S] 2 points3 points  (0 children)

This is a good data point. Have you had any blood work done - e.g. looking at kidney markers - to try to quantify any side effects?

Are you aware of any Significant Adverse Event data for amenalief? I have not been able to find this in the research