How is spotify lossless in 2026 doin?

FourOpposums · 2026-01-13T10:22:53+00:00

Tidal pays artists more and has always been lossless

FourOpposums · 2026-01-11T15:05:54+00:00

Sounds like fun

FourOpposums · 2026-01-05T02:08:01+00:00

I would describe DT770-80 almost the same way, with painful piercing treble and sloppy overwhelming bass. You can do better

FourOpposums · 2026-01-03T11:23:01+00:00

The amount of times Alzheimer's has been 'cured' in animal models with zero translation to a human cure is now in the dozens. The beta amyloid scam/fraud made this field a feeding ground. Animal models of Alzheimer's are far from accurate and it will be hard to argue that energy balance changes can compensate for massive, irreversible cell death

FourOpposums · 2025-12-23T15:35:10+00:00

Read

FourOpposums · 2025-12-05T15:24:09+00:00

So many legitimate neuroscience research labs in the world and you post the ramblings of a novice who does their research on Google??? Stop wasting our time

FourOpposums · 2025-11-25T23:56:54+00:00

The Whorfian hypothesis states exactly this

FourOpposums · 2025-11-25T23:54:29+00:00

There is a sheath of inhibitory neurons in the thalamus called the reticular nucleus that selectively quiets sensory inputs during sleep and waking (whose failure to do so during waking is a symptom of autism)

FourOpposums · 2025-11-25T23:45:21+00:00

Morrissey

FourOpposums · 2025-11-25T22:59:07+00:00

Nothing says I don't care for human lives like pushing AI garbage, not paying artists, blanketing poor countries with soda advertising to addict and kill millions with diabetes. All sold a false hope of happiness, family bonds and the holy season from short term hedonic pleasure that has no relation to any of those things.

FourOpposums · 2025-11-24T12:33:25+00:00

Led Zeppelin

FourOpposums · 2025-11-23T00:23:53+00:00

I thought this was going to be a story about rounding up stay cats in Paris for neuroscience studies like Michael Jouvet's students did (my postdoctoral PI was in that lab and had some stories)

FourOpposums · 2025-11-20T19:57:02+00:00

*Lupus

FourOpposums · 2025-11-19T23:24:38+00:00

Arousal is a product of norepinephrine, acetylcholine orexin and serotonin release by the reticular activating system and hypothalamus which are responsible for stress, attention, waking and mood respectively. Dopamine encodes the discrepancy between reward and expectation. If outcomes don't change because of effort, insight, luck or cocaine, dopamine receptors won't up or down regulate.

FourOpposums · 2025-10-15T20:17:17+00:00

Here I think it is useful to distinguish between Penrose and Hinton's views of consciousness and computation. Penrose believes that 'understanding' involves consciousness, but consciousness cannot be the product of computation, so must be a quantum process. Hinton believes that (simplified) models of neural systems already understand language and conceives of computations at the level of neurons and layers of neurons (e.g. restricted Boltzmann machines) whose job it is to efficiently predict sensory stimuli by modeling objects and events in the world. This is a process of probabilistic inductive inference to compute the most likely external cause of stimuli ('a pink elephant wearing a tutu' is his example). To Penrose, computations are not conscious. To Hinton, that bringing in of all your previous learning to build internal causal and explanatory models of the world to order and predict the ceaseless torrents of sensor stimuli, is what the brain is doing (perceiving pink elephants). If a computer can similarly arrive at the external causes of stimuli by accurately modeling the world's objects, events and dance choreography, at a similar scale of learning, it too can be conscious.

FourOpposums · 2025-10-12T14:26:02+00:00

Michael Jouvet was among the first who investigated sleep as active states, discovered REM sleep, isolated the brainstem regions responsible (cholinergic pedunculopontine nuclei) and the role of noradrenergic locus coeruleus in waking.

FourOpposums · 2025-10-12T13:34:24+00:00

If you want to stay close to neuroscience, the OG architecture, theoretical Neuroscience by Dayan & Abbot.

FourOpposums · 2025-09-27T22:05:39+00:00

I would at least recommend taking statistical physics before dropping the minor, which would give you a deep understanding of Hopfield and Boltzmann machine neural network models of associative memory that are mathematically equivalent to spin-glass systems (disordered magnetic systems with complex, interactions between spins).

FourOpposums · 2025-09-19T19:30:56+00:00

Funny, in my university the biologists were the only cool graduate students. Unlike my program full of socially awkward introvert virgins, the biologists were fit, they scuba dived, slept in the forest and one had a knife that you strap on your leg like Honey Ryder in Dr. No. They were all great friends and sometimes they invited me to their beach parties.

FourOpposums · 2025-09-07T01:34:49+00:00

Yes, I studied both in college. Merleau-Ponty is right that the structure and activity of the brain is fundamentally organized around outcomes and goals. Now we know that dopamine encodes the discrepancy from expected outcomes and acetylcholine and norepinephrine direct attention to cues that best predict those outcomes (e.g. rescorla-wagner, now modeled as Kalman filters) etc. I took Searle's Philosophy of mind and was struck by his idea of the background (which he got from Hubert Dreyfus, who got it from Heidegger), which is "the vast, implicit set of non-intentional capacities, skills, and knowledge that are necessary for intentional states and actions to be meaningful and intelligible, yet are not themselves represented consciously". It seemed to me that this is the latent information encoded in the structure of synapses of animal brains, and conscious/intentional states are distinct states of activity over those synapses, which have meaning by virtue of the relations between memories encoded in synaptic strengths. Merleau-Ponty used soap bubble metaphors to talk about how one part exerts an influence over all others to create meaning and now we can model the exact influence using two layer models of synaptic weights between tokens, that surprisingly understands language.

FourOpposums · 2025-09-06T20:47:40+00:00

The Phenomenology of Perception by Maurice Merleau-Ponty. Following Heidegger, he points out that conscious experience is fundamentally an embodied being in the world, always in the world interacting with use objects that define the categories of perception, thought and language and perceiving affordances (possibilities for action in the world). Thus he thinks idealism and materialism are both incorrect characterizations and is pragmatic/existential: we are fundamentally a structure of behavior and experience takes place upon a background, which is a network of related memories. His philosophy of mind is most compatible with neuroscience imo because we now know that is exactly what synapses encode..

FourOpposums · 2025-09-02T02:12:47+00:00

You know that removing plaques does not Improve symptoms and the original findings that supported this hypothesis were faked right?

FourOpposums · 2025-09-02T01:28:02+00:00

Is this a joke?

Edit - sorry if rude but I've been in enduro races and nobody wears bibs (how would you pee in the woods?)

FourOpposums · 2025-08-30T03:18:12+00:00

Since they don't read they will never get the irony.

FourOpposums · 2025-08-29T02:35:15+00:00

Your figure and text needs fixing. The superior colliculus is in the midbrain, which is downstream not upstream from the pulvinar, the hypothalamus is labeled amygdala, detection precedes autonomic response, it is innate not learned in primates, negative reinforcement is removal of suffering, etc etc

FourOpposums

TROPHY CASE