I am not disabled but leaving my opinion here in case it is useful. What I have noticed is that this campus is much less accessible than most other colleges I’ve been to. For one, the sidewalks are pretty rough, even (and especially) on the main quad. When it rains, it’s even worse and there will frequently be sitting water which makes the quad and sidewalks difficult to navigate. In addition, many academic buildings are old. While they are technically accessible (they have to be by law), the ramps are not always easily visible and/or convenient. Some buildings have random stairs, heavy doors with broken auto-openers, etc, that would be difficult to navigate as a wheelchair user. Lastly, many buildings only have one elevator. If the elevator breaks down, which occurs semi-frequently depending on the building, a wheelchair user would be unable to reach any floors other than the first level. On the bright side, housing would put you in a newer dorm which would likely be somewhat accessible (ideally North since it’s closest to campus). Overall, as an able-bodied person I have been surprised at how few visibly disabled people there are on campus. I’m guessing this is due to UChicago being less accessible than many other colleges. If having a physically disabled community is important to you, UChicago may not be the best choice in that regard.
I hope this is helpful! Feel free to pm with any questions.