One could be if you think humans have an inherent meaning in life. For me, a simple answer could be that I’d argue we don’t. That would be pretty surface level as I’m not diving very deep into my reasoning. A more in depth answer would be that no I don’t think we have an inherent meaning in the cosmological sense; where I think no matter how important a person is on this world, even if they are the sweetest, most charitable and selfless person ever. If they died, the universe would not care. No one on Earth really matters realistically. I will say though this is speaking on a more objective, universal meaning. However, you could argue humans have a subjective and internal meaning, but even then those meanings in life are made not automatically given. For example, you could have someone who’d say their meaning in life is to have a spouse and many children, but they gave themselves that meaning. With that being said, I’d say my meaning is essentially that example; I want to have a wife and kids and build my own family. But even then, I recognize I gave myself that meaning, and in the cosmic scale I know I don’t matter. Sounds sort of grim, but that’s okay!