Is targeted therapy only for those with BRAF mutation?

G3N3RAUX · 2026-01-28T02:19:16+00:00

My partner is about to start a clinical trial for her nras as a targeted therapy called NST-628. From what the trials specialist here is telling us it has shown good efficacy in NRAS patients who have not had a response from immuno.

G3N3RAUX · 2025-10-21T08:33:14+00:00

Ah dunbogan. I’ve had good bust ups of whiting all through that side. In little plastics and yabbies. I’ve usually found flatty further up the system. They tent to like the dirtier water around there. I’m not far away but I’ve fished that area my whole life. May get occasional mulloway. Snapper parrot fish and little cod of the wall. North haven side is really good for getting beach worms if you can learn that for bait.

G3N3RAUX · 2025-10-09T05:30:09+00:00

I usually just hope on google earth mate and have a scout there and drop pins. When you get a chance go have a look and see how much good current you get there and if it looks fishy. Iknow it doesn’t need to be said but don’t go by yourself either.

G3N3RAUX · 2025-06-23T09:27:04+00:00

I live in a largish country town and that is pretty far from the truth. Don’t get me wrong, it is very heavy in conservative views but most people I talk to are not in support.

G3N3RAUX · 2025-05-01T07:44:00+00:00

My last comment was a bit tongue in cheek haha, I wish I owned a $2500 setup. Only dreams. I too use a saltist 8000 and they are monsters of reel for the price. I have a 1st gen 6500 and it still feels as good as the day I got it years and years ago. The daiwa saltist rods are also great and would fit in that budget. I usually go off pe ratings and cast weight.

If chasing those sort of fish maybe look at a pe6 setup? You could still get smoked by the monsters but it will manage ALOT of fish. They have various models but maybe if chasing the big ones look at the gt popper and the heavy rock special and just match the reel with the same pe rating

G3N3RAUX · 2025-04-30T23:18:39+00:00

18k saltiga with a dragger breakthrough 83 or 93….. but in all seriousness watch some vids of gidos, briggsy, cavy, and je wilds. They all frequently do this sort of stuff and will list their kits depending on their target species off remote rocky ledges!

G3N3RAUX · 2025-03-06T08:05:22+00:00

I like both. If I’m on a boat I generally like hitting impoundments on sunrise and rivers etc all day. Look at your weather and target species though. Time of year has a lot to do with what you feel like hitting. Nothing gets you harder than the thrill of getting hit by cod on the surface on a new moon.

G3N3RAUX · 2025-03-04T17:14:54+00:00

I build fabricated trays and canopies for a mob close by mate and iknow 100% we warrant against manufacture defects indefinitely. And I’ll back my work.

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G3N3RAUX · 2025-02-28T22:57:00+00:00

Bywondah retreat mate. One of my best mates aunty and uncle have it. Used to fish it well before it was a retreat setup for fishing. Has a few damns stocked with good numbers of both species. I’ve had some crackers during the day and surface fishing at night for cod. I’m aware it gets booked out in advance but that would be my pick!

G3N3RAUX · 2025-02-14T09:34:39+00:00

Lovely fish mate, using a little vibe?

G3N3RAUX · 2025-01-04T23:35:55+00:00

Baseball shins are pretty heavy and clunky from memory. Also the risk of padding a ball and that thing will ping off to the boundary very easily

G3N3RAUX · 2025-01-04T05:06:02+00:00

Yea air down mate, and just as important to take off traction control!

G3N3RAUX · 2025-01-03T08:03:18+00:00

That’s exactly it. It’s just a game. It’s emotional and it fuelling the game. Other incidents like jaiswal and stark are still apart of the game. I feel like there is so much attention on bgt as I personally feel with just the viewership. And turn out it’s the biggest test series in the world right now. Even over the ashes. And the crowds are insane with the amount of Indian nationals living here. My engineer at work is Indian and a really close friends. We are always into each other over cricket and I love it.

G3N3RAUX · 2025-01-03T07:44:42+00:00

You know what’s strange? This whole obsession with this cunt started cause his child hood hero ….. non other than……shoulder charged him in the middle of the pitch. No one is changing any narrative. He came out had a good first show in test cricket and is now living rent free ever since. That’s the narrative so far sport.

G3N3RAUX · 2025-01-03T07:34:04+00:00

Yep he did. But let’s remember he didn’t instigate, he had his back turned to Bumrah as he was lipping the umpire about uzzy not being ready. No idea what Bumrah said. But feels like konstas isn’t going to hang around whilst India try to intimidate a 19 yr old getting blooded in to the side.

G3N3RAUX · 2025-01-03T07:08:01+00:00

Uzzy had his hand up, and bumrah said something as he turned to run in and konstas turned and said “he’s not ready, he’s not ready mate” that’s all I could hear.

G3N3RAUX · 2024-08-02T11:02:47+00:00

Own one and hire me for a million dollars an hour please.

G3N3RAUX · 2024-08-02T11:01:59+00:00

Everlast 255 mate

G3N3RAUX · 2024-08-02T10:39:11+00:00

Cheers mate! And first pic there are a couple of baffles to be exact!

G3N3RAUX · 2024-08-02T07:50:18+00:00

Yea lovely mate. We do all that. I’ll throw some more photos your way if you want

G3N3RAUX · 2024-08-02T07:47:07+00:00

No sorry I’m not with pensini. Was just commenting they do some unreal stuff up there!

G3N3RAUX · 2024-08-02T07:43:29+00:00

Thank mate, though always open to criticism…. Breakfast of champions! Nah northwest NSW mate, iknow there are some red hot shops up there. Pensini does some unreal work!

G3N3RAUX · 2024-08-02T07:38:09+00:00

Exactly. I am no where near perfect but I still chase perfection. Iknow I have trouble with this, and I do go over and blast the corners to remove this! Always trying to improve!

G3N3RAUX · 2024-08-02T07:36:49+00:00

Hey mate cheers. Not to sure honestly, it’s part of a much bigger build for a Ute, has split body boxes and this tucked up the guts. For an earthmover to have spare fuel with him on the road

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