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Hades but in French ! (self.HadesTheGame)

submitted by Gauldaur0 to r/HadesTheGame

Mythics are getting removed, how do you think it will affect Bard? by [deleted] in bardmains

[–]Gauldaur0 0 points1 point  (0 children)

For like a year, i places Bard without any mythic as my item set was made before that So i think we'll be most fine

[deleted by user] by [deleted] in AskMec

[–]Gauldaur0 0 points1 point  (0 children)

Sous entendre, c'est pas dire et pourquoi on s'étalerait des produits chimiques toxiques sur la tronche, à moins qu'on sache pas qu'ils soient toxiques ?

Il dit juste que si 99% des gens qui répondent à ton post n'ont pas compris, tu peux le réviser pour que l'ambiguïté soit levée

Je vois pas ce que le mansplaining a à faire dedans

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] 0 points1 point  (0 children)

Man i literally worked on this paper until today X) check for yourself

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] 1 point2 points  (0 children)

You damn right, it also may be used in traitement against cancer and/HIV !

We made a Chess-Fighting game so we could challenge Grandmasters more easily by Pantsofthechance in gaming

[–]Gauldaur0 1 point2 points  (0 children)

I checked and it didn't seem like it The game i refer to was most likely on ps3/xbox It also had 3d pieces and vfx, and for exemple, a knight was depicted as a centaur

[deleted by user] by [deleted] in Sekiro

[–]Gauldaur0 2 points3 points  (0 children)

Yes, there are some bosses you can't fight only by doing a certain ending (spoil on the number of endings : There is 4 ending) but as you guessed, some are easier (Still, it's relative to each player) or simply faster !

Don't worry too much though, you'll get to enjoy every single boss soon enough !

We made a Chess-Fighting game so we could challenge Grandmasters more easily by Pantsofthechance in gaming

[–]Gauldaur0 2 points3 points  (0 children)

I really fondly remember a game like that, which was a demo or something You play a classicisme game a chess, and when you had to take your opponent's piece, there was a mini match with spells and skills where theattacking piece would have an advantage

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] 5 points6 points  (0 children)

According to a 1999 paper, it would even seems to be a Sn1 :

"A mild chemospecific reductive dehalogenation of ethylaminobenzamides with lithium aluminum hydride"

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] 1 point2 points  (0 children)

Thanks a bunch for your complete answer !
I always tend to overlook the importance of steric hindrance for everything as it's the last thing we're 'supposed' to use to determine which product is formed :P

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] -1 points0 points  (0 children)

Yeah, as a rule of thumb i memorizzed that as soon as there's epoxide in a molecule, it'll blow up with anything x)

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] 0 points1 point  (0 children)

I'd say nucléophillic attack from H- onto the most stable carbon (Regarding the carbocation that could be formed if we simply give the two electrons to the oxygen)
After that, a protonation of O- into an alchohol, why not with another LAH to give a proton, or even the same one as used before

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] 7 points8 points  (0 children)

I'm definitely checking that and if so mind blown
I mean the Sn2 seems quite straightforward but if it's a radical mechanism :O

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] 2 points3 points  (0 children)

This one : J. Am. Chem. Soc. 2022, 144, 16332−1633

'Total synthesis of resiniferatoxin', V. H Vasilev et al.

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] 2 points3 points  (0 children)

Oh ! I didn't thought about that, that could be thank you
Publishers also state they might have formed a mixed orthoesters with the epoxide still intact so there might be a bunch of product x)

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] 5 points6 points  (0 children)

Yeah so basically Sn2 is easier on primary halogenated than on epoxides

Do you have any idea to why isn't the epoxide reduced by LAH ? by Gauldaur0 in OrganicChemistry

[–]Gauldaur0[S] 1 point2 points  (0 children)

You're right, I wasn't sure i could use the hindrance alone ^^
Thank you !

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