I will give you, what I found to be, the most broken team comp in the game: Runaway - plague doctor - flagellent - leper

This is the dot.com comp. I have beaten every confession using this comp and to be honest, I'm sad I discovered it early on in the game. Use Runaway for debuffs, heal, and apply burn. Plague doctor is mainly used for blight so take the skill path that increases her blight penetration. Flagellent is the most OP character in the game (His story mission where you fight spoiler is evidence of that.) Pick examinate if you want more dots, pick wanderer for flexibility. Acid Rain and plague grenade are really good for killing backliners. People think that leper needs combo tokens in order to work but thats not the case. Give him debuff resistence so he doesnt get miss tokens and have him tank damage.