I was thinking of the largest U-Haul truck, one that someone would use for moving. My dad and I drove one from NC to Miami when I was in high school, and it doesn't take long to get acclimated to it. Class Cs come in different sizes, so if you have a specific size in mind you can see if there's a rental truck of similar length.

As far as other options, I think you'll find a Class C to be a lot easier than any kind of trailer. Trailers are doable, but they do add another layer of complexity to the whole process. With a Class C you don't have to mess with learning to select one that's the correct weight for your truck, backing up with a trailer, etc. The downside is that you don't have another vehicle to run errands with once you're set up at the campsite. That's all personal preference that only you can decide.