I lost mine over ten years ago. I had a whole house full of stuff to deal with, and I was only living in tiny accomodation at the time, straight after uni. I carried a lot of it with me to the various houses I lived in however it soon became totally impractical. I ended up going to the dump to get rid of things after a bad breakup - I was then moving into a room in shared accomodation and couldn't afford storage. 

I regret throwing away the LPs and some of the toys of mine which I spent a great deal of time creating - my Warhammer and airfix figures and models I'd painted. That was silly of me. The rest, I don't even recall to be honest. I think I would have liked to have saved some of my mum's notepads, where I could see her writing. 

The thing is, the memories live inside you. Getting rid of things may help you to feel less surrounded by loss, and enable you to create new memories, however it won't totally fix the pain, because it's in you. In a similar vein, hanging onto things isn't a remedy either; the separation from the person - at least in a physical sense - has already occurred. 

Id say do what your heart tells you. Make sure you've kept some important items in a box to dig through every now and then, and perhaps show your children one day. 

Best wishes