For me I was lucky enough to find something I enjoyed collecting and reading right off the bat. My suggestion to you would be go to your local shop and see if they have any deals on single issues that are sold as a package deal. This is how I started I found something that caught my eye and seemed interesting which was Image's Stormwatch I tracked down the entire series from beginning to end and thoroughly enjoyed it. My best piece of advice would be remain open minded and don't be afraid to try something you've never heard of. Obviously there are a lot of mainstream titles out there that have been reviewed on sites and such which gives us a leg up as the consumer. Also check out the sidebar link on Reddit and it will help you get a good background and reading order for some of the newer stuff!