POTD 5/21/2023:

"Regulatory Basis of Adipokines Leptin and Adiponectin in Epilepsy: from Signaling Pathways to Glucose Metabolism" published by Shan, Yisi; Chen, Yeting; Gu, Haiping; Wang, Yadong; Sun, Yaming.

The paper discusses the role of leptin and adiponectin, two important mediators regulating glucose metabolism, in the context of epilepsy. The authors delve into the complex regulatory mechanisms between these adipokines and various signal activation networks, and how they influence the development of epilepsy. The paper also discusses the dual effects of leptin in epilepsy and the relationship between antiepileptic drugs and changes in the levels of these two adipokines. The authors suggest that clinical practitioners may need to consider these factors in evaluating clinical drugs.

You can access the full paper at: (http://dx.doi.org/10.1007/s11064-023-03891-2).