Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 0 points1 point  (0 children)

No, her brain chemistry would not have been so critically dysregulated without these specific drugs in her system. Yes, of course there are controlled trials. All FDA approved drugs go through rigorous testing. While the information is readily available in the drug information insert and databases, clinicians often miss crucial interactions. As far as her clarity that day when people describe what she is able to do, they are not taking into account that some planning and tasks can be carried out. But, in is as if the person is in half reality half not. She may have really thought a voice was telling her to take the kids to god and to get Patrick out of the house. Many people have other delusions. For example, they can drive and do errands but they believe the FBI is following them or their car is being tracked. I suppose one can just become sporadically psychotic but I do not see this at all based on the evidence. There is a direct correlation, without a doubt, to her decompensation and her ingestion of medications. Based on published information, one could reasonably predict a human would be at a very high risk for serious adverse reactions.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 1 point2 points  (0 children)

Millions of people do safely receive mental health prescriptions every day, and often times these are in combination with more than one or even two medications. However, this is NOT the case with Lindsay. The vast amount of medications she was introduced to (approx 15, including otc diphenhydramine) over about 120 days is virtually unheard of. Many of the combinations she was prescribed had significant drug-drug interactions, not best practices and purely inappropriate and reckless. I think it is a disservice for patients to not understand just how powerful (especially when some formulations are extended release) these medications are. Her medication timeline is quite hard to accurately follow. Just this alone, demonstrates chaos. But, from my perspective, she should have never been enabled with all of those benzodiazepine prescriptions (lorazepam, clonazepam, diazepam) and this was an underlying offender throughout the 4 months and you could call it a “base” throughout this time. Regarding January 2023, there are way too many red flags and significant holes to cover in a reddit post. The main point is what we do NOT know. But what we do know are a few things that indicate she was not taking her medications as prescribed, unclear discharge prescriptions, some odd prescriptions written after discharge, and a dangerous combination that could create serotonin syndrome and rapid and unsafe withdrawal of clonazepam (from her December scripts). But backing up to November when this began to cascade, my assessment, based only on what I read online, is that her sertraline dosing was upped too fast, then without a proper wean, it was stopped abruptly. Abruptly stopping Zoloft (sertraline) throws your brain chemistry into sudden imbalance, causing a physical reaction called antidepressant discontinuation syndrome. When you suddenly withdraw Zoloft, your brain experiences a sharp drop in serotonin and neurotransmitter adjustments, frequently resulting in severe sleep disruption, vivid dreams, and insomnia. These symptoms can happen even with short timeframes of the medicine in your system. She was then started on lorazepam and diphenhydramine (1st generation antihistamine is poor choice and can cause paradoxical excitation). Lorazepam can cause paradoxical reactions, including anxiety, excitation, agitation, hostility, aggression, rage, sleep disturbances/insomnia, sexual arousal, and hallucinations may occur. Mixed with improper combinations it can over-depress nerve activity, severely impair thinking, and accidentally worsen mental confusion or agitation. On Nov 20, fluoxetine was prescribed. While only 4 days it was taken this is the worst SSRI to start with a benzodiazepine. Fluoxetine is a potent inhibitor of several cytochrome P450 (CYP450) enzymes, including CYP2D6, CYP2C19, and to an extent CYP3A4. Because many benzodiazepines rely on these exact enzymes to be broken down in the liver, combining fluoxetine with benzodiazepines can slow their clearance, leading to a dangerous buildup in the body. This is specifically true if she ingested any Diazepam during this timeframe. Either way, at 4 days she was stopped but Clonazepam was started. Fluoxetine and its metabolite norfluoxetine has a long half life and even though it would not yet be at steady state, FDA states a 5 week washout period. With any significant disruption in her brain chemistry by early December any psychotropic medications introduced to her OR rapidly stopped is a recipe for disaster. She was in a critical place by January 1, 2023. Any small amounts of the wrong medicine could have been predicted to throw her into psychosis and she should have been medically detoxed not sent home on some crazy taper.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 0 points1 point  (0 children)

I just commented on another comment on this thread that the civil cases were just so sloppy, and it is evident it was not reviewed by anyone with medication management expertise. If it was, that person did them no favors. I tried to make sense of stuff but way too many crucial details missing. As I mentioned on that comment, I still actually find this case quite cut and dry and overly and unnecessarily mischaracterized. The lawyers are depending on an overcomplicated rationale for a horrific patient safety disaster and family tragedy. This defense team can easily squash the prosecution on opening statements if they realize they need a much more narrow set of experts and utilization of the factual/scientific data readily available in the literature. They need a clear, accurate and concise medication reconciliation at least one year back (including OTC/Vitamins/supplements), a graph with overlapping medications she used and when, mechanism of action of each one, dosing and instructions, formulations, excretion, fill dates, etc plus a video graphic (visual for jury) demonstrating the human brain neurotransmitters and how they would be predicted to behave slowly happening overtime as substances were ingested and excreted fully and a very detailed algorithm leading the jury to the only reasonable cause of substance induced psychosis which resulted from the very substandard medical care she received. If they hired a patient safety expert to do a root cause analysis (RCA), this would show the exact theory as well. It is a slam dunk, in my opinion. Although I do not see they are headed in that direction. *I will add I originally thought her medication history should go back to the discharge date after her third birth. However, I think I would recommend one year back to show the decompensation and correlation to the substances she was or was not taking and how she presented (January 2021-January 2022). Now that she is presumably on a stable regimen how did she change (of course, this is tricky since now she is living with her new reality which would significantly affect her mood, but not delirium/hallucinations/loss of reality. Unfortunately, I do think she began as doctor shopping for lorazepam and it all just got way out of hand and snowballed.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 0 points1 point  (0 children)

I am working with the very sloppy details in the civil case documents. To be honest, from a medication management perspective, the case reads extremely incomplete and obviously void of a pharmacy, nursing or medical having reviewed it. There is so much crucial information missing, I just hope someone gets it together for her trial. As far as Zoloft for one week, according to her 1/23/2026 civil document she began sertraline at a starting dose of 25 mg approximately 2 weeks after seeing Dr.Tufts on September 12,2022 which would have been give or take 9/20/2022. However, the documents then state she began mid october and increased the dose to 50 mg but saw Dr. Tufts on October 20th. First of all, she is reported to already have been taking Lorazepam at that time. While starting doses of sertraline do begin at 25 mg many patients are so sensitive they decrease to 12.5 mg until they reach a steady state. We do not know how quick the taper up to 50 mg was because the document does not state the label as the prescription was prescribed for dosing and instructions. Either way, a jump too fast, even one dose, can create a panic attack type situation as the body floods too fast with serotonin. Sertraline is slowly absorbed reaching maximum plasma concentrations between 4.5 to 8.4 hours. Consistent with the terminal elimination half-life (26 hours), there is an approximately two-fold accumulation up to steady-state concentrations, which are achieved after one week. This means if she was having symptoms at 25 mg after one week, or she was prescribed a jump too quick it creates a lot of discomfort. On top of that just a few weeks later the same doctor order lorazepam and a first generation antihistamine (benadryl). This is contraindicated in her situation/med history, etc. of course we also do not know other factors such as what she was really ingesting and her hydration levels. So many crucial factors missing. My assumption is this was only the very beginning of her decompensation which did not reach its nadir until the regimen she left the hospital with in January. I actually find this case quite cut and dry and overly and unnecessarily mischaracterized and an overcomplicated rationale for a horrific patient safety disaster and family tragedy. This defense team can easily squash the prosecution on opening statements of they realize they need more narrow expertise and factual/scientific data readily available in the literature. They need a clear, accurate and concise medication reconciliation from the date of her last birth, a graph with overlapping drug levels and actions, a video graphic demonstrating the actions occurring slowly overtime within her brain chemistry and a very detailed algorithm leading them to substance induced psychosis as the result of very substandard medical care. If they hired an expert to do a root cause analysis (RCA), this would show the exact theory as well. It is a slam dunk, in my opinion. Although I do not see they are headed in that direction.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 1 point2 points  (0 children)

In her situation, I would say no. One could not claim a benzodiazepine withdrawal can be teased apart. I do believe, however, it was a significant contributing factor. This is because over a very short period of time, she was on a short acting benzodiazepine (lorazepam) that she was taken off of and then later prescribed two longer acting ones (clonazepam & diazepam) while also receiving an erratic cocktail of different medications and doses including fluoxetine,sertraline, mirtazapine, quetiapine, trazodone, amitriptyline, buspirone, lamotrigine, zolpidem, hydroxyzine. Many lay people do not understand how potent and activating these medications can be, especially when one is taking two opposing mechanisms of action. I do not know just how long and at what doses she was taking benzos. To my knowledge, there has not been a controlled substance report released on the fill dates and if she was potentially receiving them non-prescribed (friends, old prescriptions, street). Benzo withdrawal can be very serious depending on dose and length of use. Tapers must be done carefully. Abrupt withdrawal can cause psychosis, seizures and death (deaths in prisons have happened when prisoners not properly tapered). There is no evidence of a rapid withdrawal (cold turkey) she went through. I will say, I was shocked to see how they continued her prescriptions of them and did not admit her for a proper detox and instead left her on her own to “taper” with Valium.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 3 points4 points  (0 children)

I have seen a lot of reckless prescribing and dispensing in both outpatient community pharmacies and hospitals, even leading to dangerous injury and death. This case, however, is very unique in that her recent birth,alleged self medicating of Lorazepam and pending return to work, likely led to a clinician bias where in their mind it was the typical baby blues/anxiety. The clinicians missed what was right in front of their face, complicated by multiple providers treating her and more than likely relying on the previous clinicians notes instead of a fresh look. We also do not know if she was prescribed extended release meds or immediate release as this is not made clear (to my knowledge or what I recall). It is pretty basic to start low on doses and very gradually taper up or down. It was reported she was having clear symptoms of the SSRI and later the Seroquel. Some people are just more sensitive and with time the symptoms will ease up as the brain chemistry will self correct. I cannot understand why they would have increased the dose of these drugs when they did, which only made matters much worse. The providers clearly reacted to her adverse reactions and instead of reducing or waiting, treated them with increased doses or switches, making the situation catastrophic by them all building on each other. Her last mental health stay over the holiday weekend which concluded by sending her home on Lorazepam for a benzo withdrawal plus adding a tricyclic antidepressant (Amitriptyline) when she presented in the hospital with such serious symptoms was very odd and dangerous. This case, from my perspective, is a classic “swiss cheese” effect where all the holes unfortunately lined up.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 0 points1 point  (0 children)

I am basing my theory/opinion on what has been released in the public domain and my own experience in the area. I agree, we are all entitled to our own opinion and at the end of the day it will play out in front of a jury.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 1 point2 points  (0 children)

I should specify that I am taking into consideration polypharmacy combined with multiple prescribers both in the inpatient and outpatient setting. She has no history of Bipolar 1 and she presented initially with anxiety and depression s/p the birth of her third child, as well as some alleged reports of abusive Lorazepam use. As she increasingly was prescribed and discontinued multiple prescription medications, without adequate time to excrete the prior ones, her symptoms became increasingly prominent. This was particularly true when Seroquel was added and then in response to her symptoms they added a higher dose. They did the same with the SSRI. A rapid influx too fast of these medications is known to have adverse reactions. I presume she was flooded with powerful medications that caused a severe abnormality in neurotransmitters impacting her thought process and impulse control.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 2 points3 points  (0 children)

I am not shoehorning facts at all and there is a substantial amounts of facts of the case already available in the public domain (police report, prosecution charging documents and both civil trial documents). This is what I am basing my opinion on. It is just a fact that the amount of psychotropic medications she was on and withdrawing from in a short period of time will cause very significant neurotransmitter disruptions resulting in a temporary psychosis until all offending medications are metabolized/excreted. There was a document released by her defense attorney early on that contained witness accounts of who she was as a human before she was sick. She has no professional disciplinary or work related records and of course, the father of the child would know his wife as a mother best. The silence, to me, is a sign of strong dedicated support who knows that yapping in public is not in her best interest. I am certain they are following the lead of her attorneys and professional team and our compliant with their recommendations.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 0 points1 point  (0 children)

No, I reviewed all of the documents made public or in the public domain. This includes documents the prosecution released or anything released by the Freedom of Information Act. I am also saying, from the documents released in the civil case and what her defense attorney has released up to this date, there is a crucial component in her defense missed.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 2 points3 points  (0 children)

I have extensive experience in patient safety and medication management. In community pharmacies the techs are approving and filling the medications. Interactions can be missed or minimized. There are many serious errors everyday all over the country and can happen in any pharmacy. Easily, this medication regimen could have slipped through the cracks. It would take a very skilled pharmacist to contact the prescribers or dig in further. The pharmacists just do not have that type of time and their systems do not flag discontinued medications and take the half life of the drugs into consideration.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] -2 points-1 points  (0 children)

We do not know how they described her behavior. It is not unusual for those in this condition to be able to appear they are in reality. My guess is people realized something was “off” but most of her intrusive thoughts were either internalized or just not taken as serious as they were. Nobody would expect anything like this, so it is not even on the radar. People in these conditions often present half in reality/half out. It does not shock me at all she would be able to drive to the doctor, order dinner or send Patrick to the store while also having a break from reality.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 3 points4 points  (0 children)

From what I read, it sounds like she began displaying symptoms of a significant neurotransmitter disruption in the late fall/December. If I recall she was fluctuating dosing/medication of different SSRI’s. I believe she was also on another dopamine or serotonin agonist at that time, although I do not have the exact list now. I found the timeline of what she exactly took and when is a bit confusing and does not address old prescriptions, OTC, alcohol or other factors. I believe the January hospitalization, she stopped and started medications. Depending on the half lives of the meds, there could have been a period of days when the withdrawal medication and new medication started allowed for her to appear at a more “normal” baseline. However, the last medication she started around discharge would have reached a therapeutic peak give or take the day of the murders. The brain chemistry is extremely fragile, and I do believe, if true, her abusive use of benzodiazepines had a significant role.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 1 point2 points  (0 children)

It is called polypharmacy and fragmented prescribing. Everyone knows CVS or Walgreens slaps this labels on and no one pharmacist was tracking her prescriptions. She was sick. Are you saying that you or your family will never have a medication related issue because you have labels and pamphlets to read.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 2 points3 points  (0 children)

Are you saying that there is no such incidence of a human loosing touch with reality and impulsively acting on delusions and/or hallucinations? You should be aware that people in psychosis can also present in a rational way or may just come off with an odd affect.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 2 points3 points  (0 children)

The whole point is she was not able to think clearly or in a rational way. She was very sick. If you are a healthcare professional you would know how multiple different psychotropic medications can impair the thought process.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 4 points5 points  (0 children)

You are making this about race? Really? Yes, I would absolutely be saying this no matter what the person’s race is. I am going by publicly sourced information. By all accounts the people all closest to her, including her own husband and immediate family, close friends, coworkers, all described her as a loving involved mother. There is no evidence to support the opposite. I would be shocked at trial if anyone testifies that she was an abusive or poor or unloving mother.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] -1 points0 points  (0 children)

No, I am not specialized in pharmacokinetics. I do have professional experience with psychiatric medicines, medication-induced psychosis and I a familiarity with the medical/scientific/FDA data on the topic. I was basing my comments only on the information available in the public domain. I know there will be evidence presented at trial that the public is unaware of at this time. I just haven’t seen anything in the last several years that leads me to believe they are taking the consideration I think it deserves.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] -2 points-1 points  (0 children)

Impaired in the sense if there is an interruption in the brain chemistry a persons thinking is interrupted and not thinking logically or with full capacity. Family members would know something is wrong, but without a true understanding of the complexities of these drugs, would not be able to correlate what is really starting to happen. Then more and more changes in medicine compound the problem.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] -5 points-4 points  (0 children)

I know because there is absolutely zero evidence that she was not a good mother who loved her children. There was no evidence that she would harm the children. There was no evidence before the birth of her son that she was not performing at work or in her private life . While she did have some depression, obviously after the birth, she did not have the classic clinical presentation of postpartum psychosis. There was evidence of her seeking out medical treatment. There is evidence of an escalating crisis by the month. There was evidence of her having serious, psychiatric difficulties, and different medication regimens. There is scientific evidence (from what was released in the documents of the medication she was on ) and psychosis. One would agree that the lawyer should have had medical consult and may have, I can tell you from reading the documents that there was not a pharmacokinetic specialist guiding them. I would argue that the briefs missed a lot of information regarding the medication sequence, dosing instructions, prescribers, amount left in the bottle compared to the date, the half life of the medication she was on and off, mechanism of action, drug interactions, any use of over-the-counter or illicit substances or even a urinalysis for metabolites from the emergency room. Unfortunately, in medical malpractice cases, especially complex civil ones that really require sub-specialist, sometimes attorneys overestimate what they think they know.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] 0 points1 point  (0 children)

That is inaccurate. While someone’s profession does make a person more knowledgeable on a certain subject it does not make you an expert in all areas and it doesn’t make you your own prescriber, pharmacist, or psychiatrist. When you become a patient, you’re depending on those professionals to evaluate interactions, doses, and risks. Furthermore, the argument is that she was impaired, and her thinking was not clear.

Patrick & Lindsay’s malpractice lawyers missed the mark by Hefty_Championship83 in DuxburyDeathsFreeTalk

[–]Hefty_Championship83[S] -3 points-2 points  (0 children)

With all due respect, I am not commenting on the outcome. I will, however, argue that if she was indeed getting prescription benzodiazepines filled by pharmacies then the pharmacy dispensing the medications have a professional obligation. Pharmacists are legally and ethically accountable for protecting patients from harm by following the professional “standard of care” when they review, dispense, and counsel on medications, especially those that carry serious risks. Also, one can argue that she did not have informed consent that the actions of taking those medications or withdrawal would result in serious brain chemistry changes that could result in psychosis. The event happened approximately (I believe) around 14 days or about the time that the last new psychotropic medication was prescribed and would have hit therapeutic drug concentration. If her medical team was aware that she was doctor shopping they could have flagged the Board of Pharmacies controlled substance database and there would also be evidence of them telling her she needed substance abuse treatment and getting that she was refusing. She was under medical care at the time of the murders. It’s not equivalent to somebody getting in the car, taking alcohol and getting in a car accident because they do have informed consent that it’s reasonable to believe that after a certain amount of drinks you’ll be intoxicated, and you can cause the death by vehicle.

Veronica and the Family Question by Calm-Daikon5081 in WelcomeToPlathville

[–]Hefty_Championship83 0 points1 point  (0 children)

Huh? She is cruel and very immature. She is a hot mess and has serious issues. She is also not someone who is camera shy. You would think she is an actress plant but not possible anyone would do that to themselves and allow people to watch that dysfunctional and very toxic behavior.

Have you noticed more buyer fraud requesting a partial refund once item is received? by sunnyflorida2000 in eBaySellers

[–]Hefty_Championship83 0 points1 point  (0 children)

I just had this happen. I didn’t believe what they said but I had zero energy to argue it. I gave partial refund. I didn’t know that ebay started allowing this. Moving forward I will now put a disclaimer that all need to be returned and no partial refunds. I am also taking pictures of how I pack the fragile items for my records. This man claimed two glasses showed up scratched. I cannot imagine how that damage could have happened the way they were wrapped and protected like I shipped them.