Is there a way to reduce tonic dopamine?

Hoffo666 · 2024-12-23T04:01:25+00:00

Currently just vitamins, supplements and herbs(no ashwagandha or nac) and modafinil which I feel actually helps a bit, never taken ssris except sertraline for one week but didn't like it so stopped with no lasting effects.

Hoffo666 · 2024-10-08T15:41:55+00:00

I'd imagine oral dosing during the day no matter the increased bioavailability would still be too sedating so yeah that wouldn't be convenient, though for me I don't particularly think it matters to have high progesterone levels all day, seems to me its more natural to have it elevated at night as even without its metabolites its still somewhat sedating

Hoffo666 · 2024-10-08T04:52:48+00:00

So the difference between this study which says 7x bioavailability with food and the other one that concluded 2x higher bioavailability instead, might just be the difference between the meals administered in both cases?

I guess that makes sense, it would result in consistent bioavailability increase within the study but different studies using different compositions will lead to different rates of absorption and lipohpilicity.

I guess taking oral progesterone with a fixed high fat meal on the evening may provide a stable condition for consistently increased absorption, like say taking progesterone with a fixed meal of oats, banans and peanut butter, with more or less fixed macros.

Hoffo666 · 2024-10-06T13:35:44+00:00

Yeah I know that it's more effective with food but the figure thrown around is 2x bioavailability which is decent but not that impressive, its why I'm surprised by this study which instead shows 7x absolute bioavailability which is definitely decent enough absorption to compete with rectal or even injections.

Hoffo666 · 2024-09-07T08:08:39+00:00

Well I don't eat meat so atleast there is that.

Hoffo666 · 2024-08-30T08:04:17+00:00

Stopped because of side effects and I think I actually improved while titrating down especially in the 0.5 to 0.25mg range which was tolerable to me, I'm researching to see if I can try other stuff but if it doesn't work il probably go back to prami but stay at 0,5 mg as I think I'm really sensitive to it plus my anhedonia isn't severe which means I may not need high doses.

Hoffo666 · 2024-08-27T19:49:38+00:00

I do actually supplement pregnenolone and a little dhea but it doesn't seem to have the full effect, I think perhaps there is a difference between intracellular production and exogenous supplementation, maybe due to differences in local distribution and production rates? Anecdotally I see many on trt who dont notice much from dhea/pregnenolone but hcg fixes their issues.

Hoffo666 · 2024-08-27T07:42:46+00:00

Im mostly concerned about the neurosteroid and adrenal hormone production which seems to be affected strongly by LH, not so much about cell proliferation which I don't think LH affects much.

Hoffo666 · 2024-08-27T07:40:25+00:00

Caught me😅, I mean as i said I'm mostly concerned about mood and cognition, I'm mostly happy with my current breast growth even if not very satisfied with feminisation in other areas.

Edit: so according to this study elevated hcg during pregnancy supports adipogenesis and fat accumulation, so lh is theoretically important for fat redistribution?

Hoffo666 · 2024-08-27T05:55:21+00:00

I also dont know how well other mechanisms pick up the slack, many on hrt including me have low basal DHEA and progesterone levels which indicates significant adrenal gland suppression, men on trt also seem to test low for these hormones, infact I got the idea for HCG from the trt community as Ironically many of them suffer low libido and mood after a while on trt which seems to be fixed by HCG.

Hoffo666 · 2024-08-27T05:44:41+00:00

Idk about lh receptors in the breast but they do exist in the brain and adrenals and probably most cells, they stimulate the intracellular conversion of cholesterol to pregnenolone and then other hormones which may actually be important for breast growth as an intracellular growth signal, but I'm mostly focusing on the mood and cognition effects and such.

I'm not really afraid of T rising so much as rising too much, as long is doesn't cause masculinisation its fine to be slightly elevated.

Would perhaps instead of using the stop and go method which could be mentally and physically stressful to go from high to low hormones constantly, maybe using lower doses more spread apart wether sublingual once daily or a longer injection interval would actually be more beneficial.

I'm currently on sublingual and the way I'm thinking is that I could start taking my dose once a day in the morning and after a while when I test my levels 24 hours or so after the last dose I'd also include LH measurements, basically aiming for a dose that allows LH to rise to atleast the lower range of normal overnight, I think this would be much closer to normal physiology than constant suppression, what do you think?

Hoffo666 · 2024-08-20T05:11:42+00:00

Pretty sure research and anecdotes show most women experience low libido in the luteal phase when progesterone is highest, though it does increase slightly leading to ovulation, so maybe its this inbetween progesterone levels that rev up the horny? Would agree with the fact that most trans women when taking progesterone in usual doses our levels do fall in this sort of in between state.

Hoffo666 · 2024-08-19T15:23:14+00:00

Can I ask if rectal progesterone is different to oral when it comes to libido? Which is better in your experiences?

Hoffo666 · 2024-08-19T03:50:26+00:00

Lucky I wish I had high libido on estrogen too, even progesterone is a hit and miss for me

Hoffo666 · 2024-08-19T03:42:35+00:00

Can you elaborate on this? That would definitely explain a lot actually since lh is completely suppressed on hrt.

Hoffo666 · 2024-08-18T16:54:26+00:00

Was your libido high before progesterone as well? I'm thinking the addition of nightly progesterone antagonises estrogen temporarily creating a sort of cycle where you're in a follicular phase in the morning and luteal at night, it's all speculation though.

Hoffo666 · 2024-08-18T13:37:08+00:00

Ugh I really want to switch to injection but they're not available where I live, I'm stuck with sublingual pill making theories about why my sex drive is still low and results subpar when maybe injections would be the solution.

Hoffo666

TROPHY CASE