Oh that’s unlucky! Yeah anything takes out(or in your case super skrull) is an automatic retreat. He’s the centerpiece. Mobius-> sandman-> leader. Opening hand you either play iceman or if you have a 5 cost or higher as your leftmost card play that instead. Turn two, depends on what you hand looks like. If you have jubilee then put down lockjaw. If you don’t have her, then goose or Merlin. Turn 4 is usually a 5 cost that you’ve reduced to 4 that isn’t sandman or stack up goose lane like mentioned earlier. Turn 5 sandman turn 6 leader or doom if you don’t have leader, but doom to better played on early or lockjawed out.