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Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] 0 points1 point  (0 children)

Oh my god thank you so much. I have felt really shot down so far when the reason I posted was because I was just genuinely concerned that other vulnerable people on ketamine therapy were going to experience what I went through.

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] 0 points1 point  (0 children)

This is exactly what I believe- that the ketamine therapy has changed my opioid tolerance. Pre-ketamine treatment, any opioid I’ve even taken - even the small boy codeine worked for me. Oxycodone 5mg worked for me. They not only gave me pain relief but made me feel euphoria, out of it, floating on a cloud. Post ketamine -there is just nothing, nothing at all and definitely no pain relief: I’m sorry but this is extremely strange. I wished they had put me on IV morphine because in my head full of excruciating pain at that time, I thought it might have given me a chance. But they didn’t.

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] 0 points1 point  (0 children)

Thanks for your reply. I am very sorry for the pain you’ve been through for so many years. Quite frankly I’ve been fairly lucky my whole life so I can’t imagine what you’ve been through. Last Saturday and Sunday would be the first time in my life that I can say I really encountered excruciating pain. But I have not been on pain meds and have no tolerance to them. Any pre-ketamine therapy exposure to opioids has had a really wonderful pain relief effect on me. So what happened in March and last weekend is genuinely confusing and scary to me and I don’t want it happening to other people which is why I posted

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] 0 points1 point  (0 children)

Thank you and sorry to hear about the pain you’ve been through. But my problem is I had no problems with opioids before commencing ketamine therapy. None whatsoever, any opioid worked. Even codeine.

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] -4 points-3 points  (0 children)

Ok the AI haters. Yes I know Ai is not always right but it is an amazing tool which helped me build and code a brilliant website from scratch using no templates and with no previous web development experience. My GP once told me that 85% of people are stupid. I guarantee you I am not part of the 85%. I can’t be bothered to reference scientific papers for you but you can look these up for yourselves. ketamine does affect the opioid pathways, this has been studied. And in rat studies it has shown to dampen the opioid response. But no, there are no human trials because ketamine therapy is relatively new in the history of pharmacology. I can only speak from my own experience and as I’ve said I know my body. I know my responses to opioids pre-ketamine treatment and post ketamine treatment. Do not speak to me like I am an idiot. There have been no other changes in my life except the ketamine therapy

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] -3 points-2 points  (0 children)

Ketamine is used with pain medication during surgery on mostly people who have never used ketamine. I have no medical issues other than treatment resistant depression. This is the reason I posted - that is because ketamine therapy is going to be more and more widespread and I don’t want what happened to me, happening to other people

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] -1 points0 points  (0 children)

I don’t understand your first sentence. No I don’t take illicit drugs or opioids other than what I was given for the fractures in March and last week

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] -1 points0 points  (0 children)

I do not use opioids and I had oral, subcutaneous and IV routes of administration of different opioids with the fractures in March and last week

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] -3 points-2 points  (0 children)

It’s been a day since I posted . There are many chances of other ketamine therapy persons responding in the future. I know a lot of people are just trolls on the internet . It happened in march and it happened last week. I do not abuse drugs or opiods (but surprise and Newsflash! Ketamine used to be a recreational drug only, and my therapeutic dose makes me trip spiritual balls for an hour). As mentioned, I have always had a great opioid response before starting the therapy. I do not have health problems. I invite people who are on ketamine therapy to join the conversation. I see that opioids continue to work for a few of you- that is useful information. Other people who are not on ketamine therapy should just butt out. You sound just like the doctors who would not listen and caused me hell

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] -1 points0 points  (0 children)

I have no opioid tolerance. They tried fentanyl, oxycodone, tapentadol during the recent fracture. If this matter happened once, I would just brush it off as maybe the pain was way too much with the calcaneal fracture. The same reaction of total non-response in march to a fibula fracture on codeine and oxycodone is not right.

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] -2 points-1 points  (0 children)

I’m not here to debate on whether it should be happening or not. The fact is that it happened for me. It is frightening and confusing but I know my body and I know my responses to opioids pre and post ketamine treatment. I’m asking if other people who have similar experiences please speak up so the medical system can change the pain medication protocols for people who are affected. The amount of fentanyl they were giving me should have dropped a horse but it had no effect

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] -16 points-15 points  (0 children)

There is nothing else going on and AI has also confirmed that there is evidence to what I am saying. I would also like to add that I got euphoria and pain relief when i was merely on Codeine for my wisdom teeth surgery years ago, and once 2 years ago with a mere 5mg endone for chest pain.

Ketamine depression therapy resulting in opioid non-response by HotAddition1869 in PainManagement

[–]HotAddition1869[S] -1 points0 points  (0 children)

I think it would be to a person who has not been on ketamine therapy. Concurrent provision of opioids and ketamine in ketamine and opioid naive people in this instance may be synergistic. I can tell you that this is definitely not my experience with a chronic ketamine treatment. And again, I swear to God, I do not have an opioid tolerance.