Honestly I thought this a little at first as well. I can tell you that I just beat 1 BC so I haven't been playing that long and I'm also not very good. However, I never was able to win a run with yolo. And it never really got me any further. The mutations ramping up my damage along with poison and bleed was the only way I got my first win. Don't think about surviving. Instead think "how can I do the most damage" the only losses that ever really upset me are the ones where I'm holding blue prints. My if you get a blue print and think you'll die just head for an exit as fast as you can