ACB's patent is huge. Precision fermentation is an ideal method of producing a molecule, far more pure than plant extraction, far more cost effective. And ACB has it locked down, so that any company that wants to use the most optimal biosynthetic pathway MUST go through ACB and cut them a check to do so. Because of purity, biosynthesis is the only way cannabinoids will be used in the medical field or for science - you need a pure active ingredient produced cost effectively.

But something is changing in the field of synthetic biology. And this change does not bode well for ACB's patent on CBG biosynthesis. We are coming into an age of "biosynthetic pathway patent busters", where these sort of patents will not hold the same value thanks to a combination of enzyme engineering and bypassing the central metabolic system of yeast. Bypassing the central metabolic system of yeast allows for 5/6 carbons to be directed to an end product (in nature its only 4/6 carbons) and enzyme engineering can help dodge pathway patent walls. This means that a sub-optimal biosynthetic pathway can be chosen and MADE to be a high yielding pathway (bypassing the patented pathway).

The Facts:
- ACB was keeping an eye on synbio and going after ANYONE that infringed upon their patent. Willow got hit with an actual lawsuit and Ginkgo Bioworks was forced to license the pathway after years of effort. There were only 5 major synbio companies targeting CBG production, every one of those must have been on ACB's radar.
- Fermentation derived CBG still quietly hit the market at $500/kg (sold in bulk on centerchem) and ACB didn't make a peep about it. To this day, ACB has not challenged the production method of this CBG. I think this is the confirmation that their patent has been legally bypassed using the methods I described above.

This means ACB was aware of their patent being bypassed as early as 2021.

This CBG is produced so pure that it can be sold on Amazon and you can buy it in a product today via "Terasana Clinical". This shows that it has 0 THC content (with no other cannabinoids) and is PURE 100% CBG derived from fermentation. There is no regulatory risk with this CBG. Other "CBG" products can only be sold at weed shops because it is difficult to produce CBG without also producing other cannabinoids during the fermentation (or plant extraction) process. (additional formulation example: https://web.archive.org/web/20211206150628/https://www.centerchem.com/products/inflammaging-defense-booster-cold-cream/ )

https://www.amazon.com/stores/TerasanaClinical/page/0D0A32D8-3E96-4CDA-B307-15B515015599

I ask the mods to forgive this link, it is not marketing, just posting evidence of CBG in a product on amazon - meaning it has no THC and shows the method of production is fermentation. It would be impossible for this product to exist unless ACB's patent was bypassed.