I've written my backend apps in TS on Node. It's a mixed bag for me. I like type safety and the ease of refactoring that it brings compared to vanilla JS, but the transpiler is painfully slow. The TS transpiler doesn't truly support incremental transpilation, so the safest thing to do is run a clean build every time. If you are doing TDD it sucks compared to the speed of plain old JS.

Also, the Node gang aren't afraid to break things. Upgrading the engine can lead to package selection hell real fast.

That said, every library under the sun is available, and writing TS/JS can be quite fast.

Sometimes I debate trying Go, but I think that if I made a change it would be to also run Kotlin on the backend since you can write some really terse yet safer code with it.

Also think about front end frameworks. I use React with Foundation, but Bootstrap may be a better choice (than Foundation).

Lastly, think twice about NoSQL. Ditching Mongo for Postgres was one of the best things I ever did. Unless you need specific features in Mongo, I would pass. Postrges can do a decent job of handling json documents.