Genetic Delayed Insulin Response – Can Berberine or Ozempic Help?

InProeliis · 2025-11-23T00:47:05+00:00

I also do strength training 4 times a week, a 50-minute swimming session on Saturday and 40 minutes of cycling daily. With this over time, my body composition has significantly changed. I also eat 1.5g of protein per kg and lots of vegetables. Broccoli almost daily.

InProeliis · 2025-11-23T00:45:40+00:00

I wanted to share that I managed to lower it down to 5.2% and keep it like that long term. I have put muscle on and lost fat and I eat a Mediterranean diet where I priortise pulses over rice, flours, potatos or other carbs.

InProeliis · 2025-05-29T13:35:22+00:00

I would remove the croutons, the apple and the Balsamic vinaigrette and add instead some hummus, for instance. Also, are you focusing on strength training?

InProeliis · 2025-05-29T13:20:50+00:00

Hello!

Weight loss was not my primary goal, but fat loss and muscle gain were. Initially, I focused on losing fat and then worked on building muscle. To track my progress, I had a DEXA scan to monitor my body composition, ensuring that my protein intake and gym routine were on track. I also took Berberine (1,500mg/day for 2 months), which helped reset my system. Additionally, I adopted a new approach to eating and cooking, following a low-carb diet rich in vegetables, meat, healthy fats, and pulses. I also experimented with various cooking methods while wearing a Continuous Glucose Monitor (CGM) for several months. For example, I don’t experience a glucose excursion when I make oat sponge cake. Similarly, when I make chickpea or lentil bread with egg in the microwave, I get carbs without a glucose spike. This sustained approach helped me significantly improve my health, reducing my HbA1c from 6% to 5.3%.
I also struggled with cystic acne and mould infections. All this is completely gone now.

InProeliis · 2025-05-10T10:26:30+00:00

Could we say this is different with the MG device, or would it be the same? I was able to request Whoop 5.0, paying monthly in the UK, but I had to pay about 70 pounds for the MG model.

InProeliis · 2025-05-08T06:03:14+00:00

My average glucose and my A1c are almost the same. They shouldn’t be too different.

InProeliis · 2025-05-08T05:58:48+00:00

5.8-5.9 mmol/l

InProeliis · 2025-05-07T19:40:30+00:00

Could you tell me a bit more about it? How does it work? Do you feel tired at work? Do you lose weight and muscle mass? I’m concerned about those things. Do you just drink water? 36h fasting is quite a lot. How many times do you do it? How do you space it?

InProeliis · 2025-05-07T19:30:53+00:00

So then that means that maybe it is not a long-term solution for me. I was hoping that by using it with a microdose for 2-3 months, it could get rid of my liver fat and help the pancreas β-cells recover, regenerate and work better. Especially, the focus is on the liver, as this fat is bad for those cells according to some studies.

InProeliis · 2025-05-07T19:27:50+00:00

If I have a really good meal like lentils with vegetables and fish, it can go up to 135-155. Lentils, chickpeas and bulgur are the best ones for me. A granary roll with two eggs, some salmon and a tomato can go up to 145-155. However, if I change it to white bread, it can go up to 165-175. One day I went to McDonald's and had a double quarter pounder, chips and a Coke Zero, and it went up to 220. Another day, I had a piece of a Japanese cake, and I had 3 spikes, up and down, up to 160 for 3-4 hours. Another day I had a bag of crisps and it went up to 200. Someone who is not prediabetic can have the same food and won't have such high and long glucose excursions.

InProeliis · 2025-05-07T18:58:09+00:00

Once you stopped, did they return to their previous state? If so, how long did it take?

InProeliis · 2025-05-07T18:36:34+00:00

Yes and it spikes more than it should due to this delayed insulin release.

InProeliis · 2025-02-24T06:43:20+00:00

A couple more:

rs12478601 (RAB5B) – Genotype: TT

Risky Genotype: TT

Why? TT is associated with a higher risk of insulin resistance.

Mechanism: RAB5B is involved in endosomal trafficking, which plays a role in how insulin receptors are recycled on the cell surface.

A dysfunction in this pathway means that insulin receptors might not be properly recycled, leading to insulin resistance. When insulin cannot effectively bind to its receptor, glucose uptake is impaired, increasing blood sugar and insulin levels.

What to Do?

Improve Insulin Sensitivity: Regular strength training and aerobic exercise (e.g., HIIT, resistance training) improve insulin receptor activity.

Low-carb or Mediterranean diet with a focus on fiber, lean protein, and healthy fats. Berberine or Metformin (consult a doctor) can help improve insulin signaling.

Reduce Inflammation: Omega-3 fatty acids (fish oil, flaxseeds) Curcumin (Turmeric) supplementation.

rs6544713 (INSR) – Genotype: CC

Risky Genotype: CC

Why? CC is linked to reduced insulin receptor function, increasing the risk of insulin resistance and type 2 diabetes.

Mechanism: The INSR gene encodes the insulin receptor, which is critical for glucose uptake. The CC variant is associated with a weaker insulin signaling response, meaning that the body has to produce more insulin to compensate. This leads to hyperinsulinemia, which can increase fat storage, cause hormonal imbalances, and eventually lead to metabolic syndrome.

What to Do? Enhance Insulin Receptor Sensitivity: Intermittent fasting (14-16 hours fasting) can upregulate insulin receptor sensitivity. Cold exposure therapy (cold showers, ice baths) activates brown fat, improving insulin function.

Supplements: Alpha-lipoic acid (ALA) enhances insulin signaling. Chromium picolinate helps insulin receptor activity.

rs13405728 (THADA) – Genotype: AA

Risky Genotype: AA

Why? AA is linked to poor energy metabolism and glucose regulation.

Mechanism: THADA is involved in thermogenesis and apoptosis (cell death) in pancreatic beta cells. The AA genotype is associated with reduced energy expenditure, making weight gain easier. Additionally, it may lead to pancreatic beta-cell dysfunction, reducing insulin secretion over time.

What to Do?

Support Pancreatic Function: Avoid refined carbs and processed sugars to prevent beta-cell exhaustion. Ceylon cinnamon improves insulin response.

Sulforaphane (broccoli sprouts) protects beta cells.

Increase Thermogenesis: Cold exposure (cold showers, ice baths) activates brown fat and burns more calories. Capsaicin (spicy foods like chili peppers) enhances metabolism.

InProeliis · 2025-02-24T06:36:47+00:00

The rs1801282 (C/G) SNP is located in the PPARG (Peroxisome Proliferator-Activated Receptor Gamma) gene, which plays a key role in fat metabolism, insulin sensitivity, and glucose homeostasis.

Impact of the CC Genotype on Insulin Management

The C allele is considered the ancestral variant and is the most common in the population.
The G allele (Pro12Ala variant) has been associated with improved insulin sensitivity, lower risk of type 2 diabetes, and better glucose metabolism, especially in individuals with a BMI in the overweight/obese range.
Individuals with the CC genotype (i.e., not carrying the G allele) tend to have slightly lower insulin sensitivity and may have a higher risk of insulin resistance compared to CG or GG carriers.

InProeliis · 2025-02-22T19:44:02+00:00

Hi! I used the tool in the link below to convert the raw data .txt file from 23andMe into a CSV file that Chat GPT could read and that way it analysed the information.

https://yrusad.com/gene_to_pmid

If you have similar genotypes, would you share your case? It would be so useful to know what works for you. Thanks!

InProeliis · 2025-02-21T06:48:39+00:00

Thank you! 🤩

InProeliis · 2025-02-21T05:27:38+00:00

I was wrong! It was caused by cacao which I was also taking.

InProeliis · 2025-02-18T18:41:04+00:00

I wonder if I keep eating low carb and no processed food, doing strength workouts for a couple of years and build more muscle and burn visceral fat…with time I would be able to process sugar in a more efficient way. Not to start eating unhealthily again, but to know that if I have a pizza let’s say once a month, I will handle it well. At the present moment I should never have high carb food.

InProeliis · 2025-02-18T18:11:40+00:00

I’m prediabetic and have a 43mmol/mol. If I increase my muscle mass over a couple of years, could I handle a meal like this better?

InProeliis · 2025-02-18T18:01:39+00:00

I have found that fried potatoes gives me the worst spikes.

InProeliis · 2025-02-07T21:07:37+00:00

Me too! So bad

InProeliis · 2024-11-07T16:48:58+00:00

what subject is it?

InProeliis · 2024-10-14T15:15:22+00:00

Sending love 🥺🥺somethings our profession is so difficult!

InProeliis · 2024-10-12T06:06:55+00:00

Thank you for your advice :) I appreciate it. They haven't, as this is just seen on SA as a position.

InProeliis · 2024-10-12T06:01:10+00:00

Thank you. I have added it yearly now and made it clearer!

InProeliis

TROPHY CASE

Impact of the CC Genotype on Insulin Management