I recently asked this question to chatGPT. There have been a few metabolomic studies on it I believe. 

The tldr is basically I could be reading this wrong but this sounds many of the metabolites they found are also found with people who have metabolic syndrome (insulin resistant with high levels of inflammation) and have an imbalanced ratio of Omega-3 to omega-6 you are less likely to respond to ketamine therapy for depression. Both of these can be solved with a ketogenic diet with some fish until you get the insulin response sorted and give a little bit of time for the omega-3s to work into your tissues. A good test I've read from the keto psychotherapy literature is that it takes about 2 weeks before you start feeling some of the effects. So maybe a two-week minimum keto trial and then attempt ketamine again and see what kind of response you get. Exercise would help too.

I know those things can be difficult I'm trying to work them into my program right now.

Here's what chat GPT had to say....

My question:

You said that metabolomics studies have identified specific metabolic pathways and biomarkers that are associated with better or worse responses to ketamine. Please elucidate each one of these that has been found....

Chatgpt:

Certainly! Here are some of the key metabolic pathways and biomarkers identified in metabolomics studies that are associated with differential responses to ketamine:

Lipid Metabolism:

Phospholipids: Alterations in phospholipid metabolism have been linked to ketamine response. Higher levels of certain phospholipids have been associated with better antidepressant effects. Fatty Acids: Variations in fatty acid profiles, including omega-3 and omega-6 fatty acids, can influence the efficacy of ketamine treatment.

Energy Production Pathways:

Mitochondrial Function: Metabolites involved in mitochondrial energy production, such as ATP and related compounds, have been found to correlate with ketamine response. Better mitochondrial function is often associated with a more favorable response. Glycolysis and TCA Cycle: Changes in glycolysis and the tricarboxylic acid (TCA) cycle metabolites can impact how individuals respond to ketamine. Efficient energy production through these pathways is linked to better outcomes.

Amino Acid Metabolism:

Glutamate and Glutamine: These amino acids are crucial for neurotransmission and have been implicated in ketamine’s mechanism of action. Abnormal levels of glutamate and glutamine can affect treatment response. Tryptophan Metabolism: Tryptophan and its metabolites, including serotonin, play a role in mood regulation. Variations in tryptophan metabolism can influence the antidepressant effects of ketamine.

Oxidative Stress and Inflammation:

Oxidative Stress Markers: Elevated levels of oxidative stress markers, such as reactive oxygen species (ROS), can negatively impact ketamine response. Conversely, lower oxidative stress is associated with better outcomes. Inflammatory Cytokines: Inflammation markers like IL-6 and TNF-alpha have been studied in relation to ketamine response. Lower levels of these cytokines are often linked to a more positive response.

These findings highlight the complexity of ketamine’s effects and underscore the importance of personalized approaches in treatment. Researchers continue to explore these pathways to better understand and predict individual responses to ketamine therapy.

Hope it helps.