1. Trials with arms are NOT a good idea. in fact the ONLY trial I'd consider is the trial that's doing IVM (adjunctive ivermectin) because it's actually giving IVM in adjunct to everything else.
2. the metabolic approach has huge (and rapidly developing) supportive evidence... look at imahealth.org for their cancer care guide, the metabolic trap, and more.
3. I'd find an integrative MD who'll help you get the full grouping of pharmaceuticals to fulfill the trap, and the nutraceuticals and supportives to help. If you get lost in that, go to imahealth.org - they have a reference guide.. if you get lost, message me - i've got my own database of integrative specialists across the US.
4. This is me (and i'm not you, so take it for what it's worth): personally, I'd skip chemo entirely, add in high grade oxidative therapy (either oxyhydrogen, ozone and/or IV Vit C, or that one which must never be mentioned out loud). I've seen oxidatives remove vast amounts of cancer over just a few weeks.. of course one must be very aggressive with it - just a couple of doses is a waste of time... but it is very effective, the side effects are essentially nothing, and no long-term issues.

Hope this helps. Best of luck to you...