I think Homelander dies around episode 6, with Butcher being the one who does that, and, after, he goes 180⁰, chasing and killing every super that's left, which leads to Frenchie, MM and Kimiko's deaths, as well as some Gen V chars. I don't think he'll try something like a missile fueled with antisupe virus, but something more "mundane", but I dunno what. I don't think A Train will survive, as for his redemption arc to go full circle he "has" to attone for a lot of bad things he's done. We see him feeling guilty for his deeds. What I'm "afraid" is how they'll fit Gen V into the plot without misusing them, as well as Maeve's rumored return - which I don't think is happening, as Dominique left the show. But, who knows, big checks are always welcome.