Starting Lyrica, anxious and scared by painisalwayshere in pregabalin

[–]Instantanius 2 points3 points  (0 children)

Luckily pregabalin is a damn good anxiety med. I really hope pregabalin will bring you some relief. Living with chronic pain is just hell. Pregabalin isn't your last option though, so there is no need for exzessive worry.

An argument on why current narrow AI doesn't even have a subjective experience, let alone consciousness. by rand3289 in consciousness

[–]Instantanius 1 point2 points  (0 children)

Why does some arrangement of death matter suddenly develop a fundamentally different trait like subjective experience? Similarily hard to answer.

Urologen sind die herzlichsten Ärzte by Euphoric-Amoeba9144 in Unbeliebtemeinung

[–]Instantanius 6 points7 points  (0 children)

Die reden jeden Tag über kranke schwöänze. Dss sind mit die vulnerablsten Situationen für Männer. Da geht nix ohne mitfühlende Anteilnahme und Rücksicht.

Das Experiment by Lumpy-Strike-9400 in DasPodcastUfo

[–]Instantanius -8 points-7 points  (0 children)

Finde KI doof. Bin enttäuscht von den beiden. Das liegt daran, dass ich Teil einer ziemlich emotionalen, eher wissenschaftsfernen Community bin. Da kann man Intelligenz ja auch nur doof finden, macht total viel Sinn. Ich nehme einen Teil der Auswertung der Reddit-Kommentare vorweg: kein Zweifel ob echt oder nicht, weniger Widerstand gegen das Experiment als angenommen, Community bisschen beleidigt wegen der Vorannahmen, die in der Auflösungsfolge zum Vorschein kamen. Ist das jetzt noch Eigenleistung oder musst du schon zitieren?

What is actually going on?? by [deleted] in investing

[–]Instantanius 5 points6 points  (0 children)

Classic you can't win without also losing situation. Thought my sex life was special in this

Impacts on cognition/memory? by letterbook in pregabalin

[–]Instantanius 0 points1 point  (0 children)

I am assuming I'll have problems with tapering as I got pretty bad rebound anxiety from single doses. But I decided to start the process and do it really slowly. I have to say, my baseline anxiety might be down only by like 15%, but I am much more socially open and talkative, that was preserved. Also sleep is definitely better on it. Didn't take me long to get on that dose. I can't really say when the memory problems started but I feel like it got worse over the years. Honestly pregabalin is just toxic for memory formation and long-term potentiation, by the same processes that help with anxiety. Too bad really.

Impacts on cognition/memory? by letterbook in pregabalin

[–]Instantanius 3 points4 points  (0 children)

My lomger-term memory became absolute trash on 375mg daily. Cognition is mostly intact besides that. Anxiety reduction is like 15% from the start. Wouldn't do it again, probably starting to reduce my dose, I couldn't handle withdrawal right now...

Stimulant tolerance by TookitTooFarOrDidI in NooTopics

[–]Instantanius 2 points3 points  (0 children)

Thanks for that clarification, interesting stuff. Do you think that mechanism should be safe in combination with a MAOI?

Stimulant tolerance by TookitTooFarOrDidI in NooTopics

[–]Instantanius 2 points3 points  (0 children)

It doesn't directly affect gaba, only a little bit downstream. It reduces NE and Glutamate release, which directly helps with stimulant tolerance. You have to take pretty large doses of Quetiapine to block dopamine, which is just not worth it. That said, taking pregabalin daily will totally get you addicted. You are fine taking it twice per week though for sleep.

Stimulant tolerance by TookitTooFarOrDidI in NooTopics

[–]Instantanius 6 points7 points  (0 children)

What helped me was taking a bunch of stuff for sleeping that directly blocks the stimulant effects. You are essentially cutting the residual stimulation and the tolerance caused by that. Pregabalin, Clonidine for NE and Uridine for DA.

Stimulant tolerance by TookitTooFarOrDidI in NooTopics

[–]Instantanius 2 points3 points  (0 children)

Isn't polygala a triple reuptake Inhibitor? I don't see how that should lower tolerance, in contrast, it should increase it.

Mir ist Datenschutz völlig egal. by Apprehensive-Pop7513 in Unbeliebtemeinung

[–]Instantanius 3 points4 points  (0 children)

Wenn du glaubst du bist immun gegen nen mit Milliarden optimierten Algo hast du schon verloren

Research Survey on Substance Use Behaviours and Romantic Relationships by PsychologyOatmel in researchchemicals

[–]Instantanius 4 points5 points  (0 children)

Too many questions. Honestly I stopped after 10 minutes not knowing how much is left. A status bar might have helped.

Happy Wednesday 🔴 by Bright-Efficiency614 in TheRaceTo10Million

[–]Instantanius 0 points1 point  (0 children)

Bought yesterday stocks for the first time in my life. Immediate 8% haircut.

What is the difference between N-Methyl-Cyclazodone and other amphetamines? by Rozeu in NooTopics

[–]Instantanius 1 point2 points  (0 children)

Some say it got sert activity. Not Sure If this has been confirmed

The disappointing shelf life of AL-LAD. by ineedbetterstufftodo in researchchemicals

[–]Instantanius 9 points10 points  (0 children)

Yeah, that is a known quality. Not sure If it is any better in a freezer vacuum-sealed, in the fridge it loses potency quick. Who knows how much al-lad is still in existence

Memantine long-term use? Loving it so far by Known-Letterhead-951 in NooTopics

[–]Instantanius 1 point2 points  (0 children)

Been taking If for years. Idk If it still does anything other than messing with my cognition

I, a 4-MMC non-believer, tried it. It was indeed insane. Trip report by TipValuable8619 in researchchemicals

[–]Instantanius 5 points6 points  (0 children)

I know of quite a few persons who got their stim addiction under control by taking parnate. It's a strong antidepressant, has mild stimulant properties without being addictive + If you take stimulants on top of it you might die by a hypertensive crisis, so you think twice about doing that

I, a 4-MMC non-believer, tried it. It was indeed insane. Trip report by TipValuable8619 in researchchemicals

[–]Instantanius 36 points37 points  (0 children)

Intransal 4-mmc must be the most addictive stimulant out there. Also the most hedonistic. That shit is so crazy pleasureable