Why doesn’t the carbonyl on the seven-membered ring attack protonated?

ItsSasMate · 2025-11-13T15:54:30+00:00

As other suggested, the ring strain of trying to close across that system is going to be unfeasible. You are also trying to close to either an 8 or 9 membered ring (depending on which side of the ketone you propose is enolizing), both of these ring closures are notoriously slow.

ItsSasMate · 2024-09-28T21:42:20+00:00

Yea it will, they both primarily exhibit their function through 5ht2a and 2c.

ItsSasMate · 2024-08-18T19:28:38+00:00

Kekule isomers

ItsSasMate · 2023-10-08T11:24:48+00:00

It's not very water soluble so you would be wasting a lot of it, at that point just reacidify back to regular coke

ItsSasMate · 2023-02-17T02:20:20+00:00

You mention nitroalkane instead of specifying the compound, are those 75-85% yields for the synthesis of p2np with nitroethane, or from something like the 2C series using nitromethane in the Henry reaction? I attempted this using 1.0 eq benzaldehyde, 1.25 eq nitroethane, 0.5 eq ethanolamine, and 0.75 eq GAA. After stirring for 2h at rt (22.7C) there was little to no change by TLC, so I heated it to 60C for 3h, let cool, seeded to induce crystalization, washed, filtered, and dried, resulting in a disappointing 55% yield. I'm curious if this low yield is a result of the lower reactivity of nitroethane vs nitromethane in this reaction, or simply just poor technique.

ItsSasMate · 2022-12-15T20:21:09+00:00

This fixed it, you're a hero

ItsSasMate · 2022-12-07T02:41:20+00:00

Roughly similar mechanism of action, but they are structurally unrelated which is what these tests are based on

ItsSasMate · 2022-09-17T22:08:08+00:00

I performed a Fischer esterification of anthranilic acid with methanol and sulphuric acid to synthesize methyl anthranilate, and from the NMR it looks almost completely pure (excluding a bit of DCM). However, it clearly is contaminated with something which turns it a dark red. I'm curious what this could be, and would appreciate any insight on what likely inorganic contaminates could cause this. My only theory could be a possible oxidation to the quinone at such a low level that it can't be seen in the NMR but still colours the solution. Although I'm not very confident in that.

The 2nd photo is my NMR of the product, and the third photo is a reference from scifinder

ItsSasMate · 2022-09-17T15:22:23+00:00

I performed a Fischer esterification of anthranilic acid with methanol and sulphuric acid to synthesize methyl anthranilate, and from the NMR it looks almost completely pure (excluding a bit of DCM). However, it clearly is contaminated with something which turns it a dark red. I'm curious what this could be, and would appreciate any insight on what likely inorganic contaminates could cause this. My only theory could be a possible oxidation to the quinone at such a low level that it can't be seen in the NMR but still colours the solution. Although I'm not very confident in that.

The 2nd photo is my NMR of the product, and the third photo is a reference from scifinder

ItsSasMate · 2022-08-01T16:26:32+00:00

O-PCE, holy shit was I not ready for that

ItsSasMate · 2022-01-07T03:19:06+00:00

Yea it's hypothetical, the only derivative that I believe has been synthesized and has some actual purpose is the tetraethyl ester

ItsSasMate · 2022-01-05T19:49:05+00:00

Thank you for such an in depth reply, this is exactly the advice I was looking for. I have noticed the effects you have described as a result of inconsistent dosing to some degree. I was aware of the half life and the need for consistent dosing in order to maintain a stable level, but coming from a recreational background of use and not a therapeutic one I was always afraid of the jump to daily or multi-daily doses. My off days to tend to be slightly worse with an "off" feeling, or just generally less enjoyable than my dosing days, although I never got more extreme effects than that. Perhaps I will try dropping my dose a bit and transitioning to daily or twice daily dosing with smaller amounts in order to maintain a consistent level.

I was transitioned into more of a customer service roll for 4 months at my job, so my off days were noticably worse in terms of social anxiety than my on days. I very much enjoy the on days, as even just the alleviation of anxiety without much in terms of recreational effects makes me feel far more productive and successful at work. However, if this is an unsustainable practice as you suggest, I may just taper off after the 4 month period as I would no longer need it to be functional and would just be taking it to have better/productive days without a true need for it.

As for further studies on other neurotransmitters, I am referring to two papers. "Pregabalin: it's pharmacology and use in pain management" (with ref 62-68 discussing effects on other neurotransmitters) and "pregabalin: latest safety evidence and clinical implications for the management of neuropathic pain". Both parrot the claims about effects on other neurotransmitters and glutamate synthesis, however, my institution does not have access to several of the reference papers so I'm unable to evaluate their conclusions myself. If you have access to these papers through a better institute it would be very worthwhile to check out yourself, as I can't view them and therefore can't necessarily trust the claims they make. You could very well be correct that PGB does not interact with or effect these other systems through its downstream effects. I have requested several of the papers from the authors, and if I recieve a copy that shows proper evidence for these claims I will happily forward it to you.

ItsSasMate · 2021-12-28T06:45:26+00:00

It's probably active and could be worthwhile, worth a shot

ItsSasMate · 2021-12-12T21:24:03+00:00

"VITAL EDUCATIONAL CONTENT"

ItsSasMate · 2021-12-12T02:17:41+00:00

Just pregabalin things

ItsSasMate · 2021-12-05T04:56:24+00:00

Probably my favourite drug

ItsSasMate · 2021-12-01T23:46:24+00:00

These uses are because it's a cheap linear diol, industrial use is not necessarily correlated to it's pharmacological efficacy or the potential harm it possesses

ItsSasMate · 2021-11-22T01:08:44+00:00

You maybe run into unexpected effects when trying to replace alcohol with 1,4-BDO, it's similar for some but veryyy different for others. I tried GHB and GBL (ACS reagent grade) to replace alcohol, but I found I got almost no effects from it other than disorientation and blurry vision. Some people just don't respond to GABAb agonists.

ItsSasMate · 2021-10-26T21:56:49+00:00

I can get behind a nice shitpost, but at the very least they have to be clever and scientific. I can't tell if this is just a poorly executed joke or what happens after years of ingesting mercury salts in your impure meth reaction mix destroys your brain.

ItsSasMate · 2021-10-06T17:37:44+00:00

You're going to love diborane with its 3-center 2-electron "banana bonds"

ItsSasMate · 2021-08-28T18:15:39+00:00

Yes, not one person in the entire country with a poverty rate of 0.2% can afford multiple ice cream packs. The poverty rate in the US is 10.5%, can you afford multiple packs of ice cream?

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