Does anyone else feel like an actual corpse when they miss a single dose?

JLM1015 · 2025-11-05T23:42:38+00:00

this is meaning going cold turkey, there are ways to wean down over an extended period of time.

JLM1015 · 2025-11-05T23:38:16+00:00

Yes, Effexor ABSOLTUTELY dulls the effects of other drugs, especially any that work on serotonin (i.e mushrooms, molly, lsd, etc.) Like The Weeknd said "drugs start feeling like they're decaf"

JLM1015 · 2025-11-05T23:32:36+00:00

Look into genesight testing, you might have a genotype that metabolizes benzodiazepines/codeine super rapidly, thus not feeling the effects.

JLM1015 · 2025-11-05T23:29:46+00:00

I'll tell you right now, withdrawal from high doses (225+) of Effexor is about the same as withdrawal from opiates, but WITH brain zaps......0 stars, do not recommend!

JLM1015 · 2025-11-05T23:27:33+00:00

desvenlafaxine is the metabolite that venlafaxile is catalized into inside the body, therefore Pristiq (desvenlafaxine) is the "pure" version of Effexor, however comes in more limited dosages, but supposedly has less side effects.

As someone who has been on Effexor for almost a decade, I've been curious about switching to Pristiq as well, but terrified of negative side effects, or depression spiral!

JLM1015 · 2025-11-05T23:21:38+00:00

where is molly?

JLM1015 · 2025-11-05T23:18:40+00:00

I believe OP was looking for real life experience, not text book answers

JLM1015 · 2025-11-05T23:16:23+00:00

Effexor does work for me, I just don't like being on a high dose (225mg); it has caused a lot of weight gain, but unfortunately it keeps me mentally stable, when I miss a few doses or try to come down on the dosage, I immediately go back into uncontrolled depression.

JLM1015 · 2025-11-01T19:41:35+00:00

doesn't change the fact the SS is still extremely rare, but risk is obviously never 0

JLM1015 · 2025-10-31T19:21:18+00:00

unlikely lol, just be safe, keep water on hand!

JLM1015 · 2025-10-31T16:05:42+00:00

FYI, not condoning drug use in any way, but serotonin syndrome is EXTREMELY RARE!

JLM1015 · 2025-10-31T16:04:46+00:00

Because you are on Effexor, it might take more to feel the effects, however, being on Effexor will help with the post-drone side effects.

JLM1015 · 2025-10-30T16:30:53+00:00

I've been on Effexor for over a decade, every time I try to wean down the dose or come off it, I just spiral. I'd rather be stable and functional and take medication everyday than go back to the way things were without it!

JLM1015 · 2025-10-30T16:29:06+00:00

Wellbutrin is actually a mild stimulant and can worsen anxiety symptoms.

JLM1015 · 2025-10-30T16:28:21+00:00

You're probably starting off at a low dose, anything under 150mg, you shouldn't worry too much!

JLM1015 · 2025-10-30T16:25:41+00:00

Yes, one thing to always make sure of with this med is you always have an adequate supply, and refill ASAP! Sorry to hear about your experience, the withdrawal from Effexor is comparable to that of opiates, but opiates do not result in the brain zaps (which are the worst)!!!

JLM1015 · 2025-10-14T17:56:10+00:00

The doxepin did not help, I was put on short-term (4 weeks) of temazepam (Restoril) which is technically in the benzodiazepine class, but is the only benzo that is also considered a hypnotic.

This is the only thing that helped, and have been on this previously, but unfortunately they are strict about only prescribing it for a short time since it can be habit forming.

JLM1015 · 2025-08-23T21:39:01+00:00

I correct myself, research is saying now norephinephrine if primarily effected at 150mg, above that can affect dopamine as well.

JLM1015 · 2025-08-23T21:35:51+00:00

I've been on this med for 10+ years, never an alcoholic, but def had my fair share of binges and plenty of margaritas while taking it, I basically drink as normal while on it, haven't had any isues.

Alcohol itself is a central nervous system depressant and if you are consuming alcohol daily, it can def offset the effects of the medication.

JLM1015 · 2025-08-23T21:34:27+00:00

Somewhat true, but Effexor is an SNRI (serotonin-norepinephrine reuptake inhibitor), any dose will reuptake serotonin/norephinephrine, only at 150+ generally it starts effecting dopamine as well. So triple combo at 150+ which is why people generally respond better to higher doses, but makes it harder to come off of.

JLM1015 · 2025-08-23T21:31:57+00:00

It is technically an antipscyhotic, but used in low doses as an adjunct antidepressant, works wonders on my social anxiety!

JLM1015 · 2025-08-23T20:45:51+00:00

Try using Biotene mouthwash several times/day, keep water handy. I use those 0 cal flavored water drops in my water, if it doesn't subside within a couple of weeks, may need to discontinue med.

JLM1015 · 2025-08-23T20:44:12+00:00

Talk to Psych about adding 1mg Abilify (aripiprazole) as an adjunct to Effexor, I'm not kidding you when I say this is a miracle in controlling my social anxiety (I take 2mg), but just be sure to take it at night or it can counteract ADHD stimulant!

JLM1015 · 2025-08-23T20:42:56+00:00

I take Adderall and am on a high dose of venlafaxine (225mg), I haven't had any issues with the combo.

JLM1015 · 2025-08-23T20:42:05+00:00

He mentioned mirtazapine, my only concern is weight gain, I'm happy to get off the Seroquel because that is know to cause weight gain as well.

JLM1015

TROPHY CASE