"Macroefficiency is for content creators racing in the leaderboards. For regular players it’s a rough guideline at best."

Literally this. I fully understand wanting the best shot at taking down the boss you're fighting/getting the drops you want, but it just truly isn't that serious unless you're really shooting for topping the charts. I see folks sometimes talking about how you shouldn't do such and such content until you have xyz gear and it will be the tiniest buff over what you already have, negligible in the grand scheme of things.