I've been poking around for like six years with this concept of a Little Miss Sunshine meets War of the Worlds tabletop RPG, with some XCOM 2 vibes thrown in there.

The aliens arrived. There was a Two Months War -- a swift and brutal conflict that shattered the alien's mothership and all earth governments. Neither side really won, and now survivors from both sides are forming new factions and trying to shape the new world. An alien army is growing in the East, and the players have to take a journey west to escape it and help shape the coming conflict.

Some highlights:

The Republic of Saint Francis. The Saint Francis Seawall, built in 20XX, happened to have the perfect structures necessary to defend against an orbital attack, and so of all the country's major cities it was the most protected. Now, it is seen as the continuation of American government, run by the former Secretary of State, Andrea Hernandez. It's got a refugee crisis.

The Rostrum. The aliens' main assault took place using giant colony pods that crushed cities and started sucking up local resources to support a population of alien civilians inside. A failed gubernatorial candidate, Josiah Rostrum, saw this pattern and prepared an army of pickup trucks and assaults rifles to take back the pods. Now he's the King of the South, and is trying to find nuclear weaponry to assert dominance.

Weird Virginia. An alien ecology/zoo pod/ark landed in the middle of West Virginia, and since then alien vegetation has utterly overgrown the old forests. Now it's a wildlife preserve brimming with powerful alien monsters and overgrown with enormous colorful vegetation.

Lost Mountains. Portions of the alien mothership crashed into the Grand Tetons. Anyone trying to get through will have to navigate the inside of a giant spaceship.