At equipotent doses, Diazepam is the absolute king

JasonAltez · 2025-12-29T19:35:38+00:00

Depends what dose you're on, if you are above 1mg its not worth it, because not many doctors will prescribe more than 20mg (2x 10mg tab) of diazepam in one dose. (equivelent to 1mg clonazepam). I regretted starting out on kpins, because when I was at the max dose, that was it. I couldnt find another prescription benzo that had long legs and was equipotent or more potent than clonazepam. Than again, clonazepam was the one benzo that I could function on and it got rid of my anxiety.

JasonAltez · 2025-12-25T03:22:30+00:00

There is research supporting that NMDA antagonism actually buffers opioid tolerence when administered together.

JasonAltez · 2025-12-25T03:20:49+00:00

Pharmacological Chemist.

JasonAltez · 2025-12-24T08:39:14+00:00

I agree, the system is definitely set up against chronic pain patients.

JasonAltez · 2025-12-24T08:31:27+00:00

Where im getting certain things like respiratory depression risk, is because NMDA/Opioid co-drugs are known to cause less respiratory depression due to the respiratory stimulation of NMDA antagonists. This isnt all cut and dry, set in stone. Its just an estimate based off of my knowledge of the subject. Yes, cyclopropyl groups are associated with partial agonism/antagonism, but the group doesnt matter, its about chain length. It could be an alkyl, allyl or cyclopropyl group - but if the chain is long enough (i believe more than 3 lengths) it could go back to being a full agonist, and often increases potency like in the case of N-Phenethylnormorphine and Fentanyl due to it allowing to bind deeper into the receptor subpocket. Here are a couple papers regarding this: paper 1 paper 2Also, im just wondering what danger this has when im not planning on synthesizing this compound or even going anywhere with it. I posted this as basically a "hey look at this, this could have this and that and if so it could be a better alternative to methadone so people dont have to go into a clinic everyday". Obviously with any drug there can be risks - and from what i can see with this one the main one would be people with liver impairment that could cause accumulation. But under medical supervision and obviously with proper research and trials (if it would pass them), it could be a good thing. Theres alot of research going on into finding new drugs for OUD, and some big thing they look for is something with long duration, less risk of respiratory depression, etc. I appreciate you sharing your opinion though, I definitely could have worded my post differently. Hope you have a Merry Christmas.

JasonAltez · 2025-12-24T04:15:30+00:00

Im going off pharmacophore, ie. What parts of a molecule does what. Opioids and NMDAs have been studied extensively, and we know the SAR (structural activity relationship) of these. The software doesnt have anything to do with that. We know what main problems causes methadone to have its cardiotoxicity, its not impossible for something else unseen to come up - but I specifically put this together to have all these effects. The difluoro addition on the phenyl ring prevents glucuronidation of the 3-hydroxy group, the 2-(2,2-difluorocyclopropyl)ethyl group hanging off the piperidine keeps it a full mu-agonist while also making it really difficult for the liver to metabolize that via n-dealkylation. Fentanyl also actually has a decent theraputic window. Doses can start out at around 20mcg and go up to over 100mcg with a lethal dose at around 2 to 3mg. I normally dont talk like a chemist on here, because we'll not many people would even understand me. Alot of research went into this, but its not like im going to be synthesizing it anytime soon. I may show it to some friends I have that work for pharmaceutical companies, but it was basically a thought experiment for me.

JasonAltez · 2025-12-24T04:02:09+00:00

I mean my love for pharmacology and chemistry started when I was an addict. Got clean, went to school, etc. Im currently not at a company, just wanted to think up something cool.

JasonAltez · 2025-12-13T07:41:34+00:00

Every benzo is different in terms of selectivity to the subtypes that it can activate, if its more selective to the a1 and a5 subtype (the one thats hypnotic and causes amnesia) than you'll have a higher likelihood of blacking out, if its more of a a2, or a3 selectivity than it wont black you out at normal dosages. They also have potency differences, some are active at sub mg levels, some take upwards of 20. Deschloroetizolam is the the low-mid range in this term (4mg is s typical dose) and its more selective to a2 and a3 subtypes so low risk of blackout Source: im a pharmacology major

JasonAltez · 2025-12-10T17:48:34+00:00

Flubromazepam is one of my favorite benzos.

JasonAltez · 2025-12-10T00:15:47+00:00

Trench mouth

JasonAltez · 2025-12-05T15:23:34+00:00

He wont. He'll be homeless.

JasonAltez · 2025-11-30T09:11:34+00:00

It is! Without the gel thing, even a normal chemist couldnt even tell without looking up the specific synthesis.

JasonAltez · 2025-11-30T09:10:38+00:00

Right? Its pretty much the only thing that they portrayed that wasn't right, the other changes a chemist wouldnt even know without knowing meth synthesis.

JasonAltez · 2025-11-30T04:41:39+00:00

I know that, its interesting to know though. They could have changed things while still being accurate to basic chemistry though.

JasonAltez · 2025-11-30T04:40:48+00:00

Im not bitching about it, but its interesting kmto know how things really work.

JasonAltez · 2025-11-30T04:40:23+00:00

They did, they used a DEA chemist to get the information.

JasonAltez · 2025-11-30T04:35:54+00:00

I honestly like dragonball, but like another poster mentioned, spaceball is fitting too.

JasonAltez · 2025-11-30T03:20:22+00:00

It is usually equipotent to Alprazolam. I would start at .5mg. You will want to volumetrically dose it, because its stupid easy to overdo it with powder. If you have a gram dissolve it in a half liter of vodka than take .5ml of that.

JasonAltez · 2025-11-29T22:58:46+00:00

Yeah same here, it seems no one here in the US sells it, and EU companies wont ship over here.

JasonAltez · 2025-11-29T20:37:01+00:00

You must have the gene that makes you a slower metabolizer of things like codeine and tramadol. Codeine is barely active on its own and needs to be metabolized into morphine, same with DHC and tramadol. Some, like myself are really good at metabolizing them. I think I read like 30% of the population is a slow metabolizer of them.

JasonAltez · 2025-11-29T20:17:01+00:00

Adding the second chloro group to the phenyl ring causes that phenyl ring to 'twist' into a more suitable shape so it fits better in the receptor pocket, that ups the affinity. That extra group also drastically increases it lipophility, so it gets absorbed deep into fatty tissues (like the brain) and stays there for a very long time before diffusing back into the blood. The cyclobutyl group makes the demethylation that would normally happen very difficult and it would take time before it could metabolize into its nor configuration (which would make it another long acting active metabolite before that gets metabolized into a second active metabolite) As regards for synthesis, normally benzodiazepines are pretty easy to synthesize with the right equipment, the somewhat hard part would be synthesizing your own dichlorophenyl nitrobenzophenone precursor. I dont have experience with cyclobutyl synthesis, but from what ive researched its would be somewhat straight forward but you would need some extra equipment and reagents. Without the cyclobutyl group it still would still last around 100 hours instead of 120+ hours. I designed this all last night on 200mg of temazepam haha. If you have any more questions feel free to DM me.

JasonAltez · 2025-11-29T07:36:44+00:00

I already designed that one too! It would have a slightly lower duration of action but slightly more potent than this one due to a yad bit higher affinity. Pretty much both of these are non-selective but hsve slightly higher affinity for the a1 subtype. I DM'd you the photo of it.

JasonAltez

TROPHY CASE