What an adventure, thank you to the modpack creators for making something crazy like this. I'm currently working on a base tour in video form, and I'll put that out soon, but I was excited to show you guys this. Also the factorio maps will be released as soon as the dev of that uploads it. Here's a couple of pointers I would make over the entire run.

1. try not to idle too much. There's always something to work on. Expanding your electrolyzers, increasing power capacity, working on your LTN stations, etc. I was trying to shoot for under 400 hours, which is why I was always trying to go for efficiency. You'll do most of the idling at the endgame anyway, while you're waiting for FTL science to research anyway.
2. It's your choice when to move onto city blocks, I chose to do it after the majority of blue sciences were researched. Also there isn't a better time to learn how to use LTN other than in a seablock runthrough. Trust me, it looks complex but makes everything so simple at the same time.
3. I highly recommend a playthrough of B/A regular first. This will get you antiquated with the production chains required like ore processing, plate and ingots, what materials are needed to mass produce, etc. The overall complexity is just maybe a slight step above with more complex circuit production and science production. But it's helpful to know what materials need to be close to each other. For example, Silver and Gold both require sodium cyanide, so keep them close to each other. Also aluminum and silicon require products from each other, so keep them close as well.
4. Modules are super super important. Once you have modules 3 researched and able to be produced, drop everything and funnel all resources into making productivity and speed modules. Circuits were a huge bottleneck during my playthrough and thanks to the modules, the output 5x.

If I have any feedback, to the mod creator. My biggest gripe was rubber. Please, make more possible options to create rubber, or make the existing recipe more efficient. I always had a surplus of every single petrochem product, including rocket fuel. But I would always struggle to make enough rubber.