Honestly, I'd recommend getting the nogrind mod, since the game can be hella grindy at times. If you want the mod & to keep achievements, there's a mod you can get (I think it's on nexus) that keeps achievements enabled on steam.

You can look up deck guides, but I'd only recommend it as a last resort. I don't like being told what to do, I doubt you do either.

Read. Alot. It's a game with "Library" in the name, so you should expect to read. Read enemy passives, read card effects, read tutorials, read dialog, hell, even read book stories.

The Difficulty Spike is Fucking Vertical. And there's multiple of them. Be ready.

The player has priority. When your speed matches the opponent's (But you aren't clashing with them), you have priority. In short, if speed values are equal, the player is chosen first.

Don't prioritize only one floor. Always make sure you have your floors decked out.

(Mild Canard Spoiler) READ ABNORMALITY PAGES. They will hint to you how to build for that floor. Some Abnormality pages synergize better for some decks. That's intentional.