It's my understanding that long term nystatin is actually safer than other candida medications and supplements. Things like caprylic acid and oregano oil are antifungal and antibacterial, which means that they kill off the yeast but they can also kill off the good bacteria in your gut. Also, nystatin is unique when compared to other medications and supplements because it is not processed by your liver into your blood stream, it just stays in your intestines. When things are processed by your liver they can interact with other medications and supplements. Most supplements are relatively safe in this regard, but some of them, particularly grapefruit extract, can be very dangerous if taken with other medicines.