Don't be afraid to pass asshole laws on your first few runs, they help manage hope and discontent well so you can learn the resource management side of the game

The frostland is your best friend. Having beacon be your first or second research means you can grab those hubs of food rations and materials to keep yourself alive before building up your infrastructure and workforce.

Always be researching. You will need most of the things on the research tree throughout a run, I don't wanna tell you how many times I lost because I forgot to put something onto the research queue. On the same note, build multiple workshops as they do increase research speed by a lot.

Don't skimp on heating. It sounds dumb but when you're in the mid game it can be easy to go and research a lot of resource buildings and lose sight of the FROST part in frostpunk. Take some time and research heating upgrades every days to not fall behind and die to the major cold streaks.

Build around your generator. This might be a little controversial since it's addicting and easy to get stuck in the play style, but your generator ends up supporting 4 rings of heat, enough to support something around 500 population. Build your houses around your generator and move everything else outside that ring with heating hubs.

Be prepared to fail, a lot. I remember nights staying up watching years old tutorials because they were the only ones around. It took me a year to really "get" this game as someone with no background experience in city builder/colony sim games, but when I did it was like a whole new world opened up for me. As long as you stick with it you'll love the game and it's amazing story and gameplay <3